1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection
Research output: Contribution to conference › Poster › Research
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- KBragstad 1327037 ESWI NEW
Final published version, 1.79 MB, PDF document
Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.
Original language | English |
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Publication date | 2008 |
Publication status | Published - 2008 |
Event | European Influenza Conference - Vilamoura, Portugal Duration: 14 Sep 2008 → 17 Sep 2008 Conference number: 3 |
Conference
Conference | European Influenza Conference |
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Number | 3 |
Country | Portugal |
City | Vilamoura |
Period | 14/09/2008 → 17/09/2008 |
- Former LIFE faculty - DNA vaccine, Ferret, 1918
Research areas
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