Probiotic yogurt in the elderly with intestinal bacterial overgrowth: Endotoxaemia and innate immune functions
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Probiotic yogurt in the elderly with intestinal bacterial overgrowth: Endotoxaemia and innate immune functions. / Schiffrin, Eduardo J; Parlesak, Alexandr; Bode, Christiane; Bode, Christian; van't Hof, Martin A; Grathwohl, Dominik; Guigoz, Yves.
In: British Journal of Nutrition, Vol. 101, No. 7, 2009.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Probiotic yogurt in the elderly with intestinal bacterial overgrowth: Endotoxaemia and innate immune functions
AU - Schiffrin, Eduardo J
AU - Parlesak, Alexandr
AU - Bode, Christiane
AU - Bode, Christian
AU - van't Hof, Martin A
AU - Grathwohl, Dominik
AU - Guigoz, Yves
N1 - (Ekstern)
PY - 2009
Y1 - 2009
N2 - A study was conducted in healthy elderly living independently in senior housing to assess the impact of a probiotic yoghurt supplement on small intestinal bacterial overgrowth. Twenty-three participants with positive and thirteen participants with negative hydrogen breath test were studied before and after a period of 4 weeks of probiotic yoghurt administration. Intestinal permeability, plasma endotoxin levels, phagocytic activity of leucocytes, cytokine production by monocytes and free radical response of neutrophils were determined. Intestinal permeability was similar for the two groups and was unaffected by probiotic treatment. Both plasma endotoxin levels and the basal phagocytic activity of leucocytes decreased after yoghurt intake in the two groups. Exposure of monocytes and neutrophils ex vivo led to an increased cytokine response and free radical response, respectively. The normalisation of the various cytokine responses was more apparent in the group with positive breath test. In addition, the plasma levels of lipoplysaccharide binding protein and soluble CD14, lipoplysaccharide pattern recognition receptors and surrogate markers of lipoplysaccharide permeability were diminished by the end of the study. In conclusion, probiotic administration in the elderly normalises the response to endotoxin, and modulates activation markers in blood phagocytes, and therefore may help reduce low-grade chronic inflammation.
AB - A study was conducted in healthy elderly living independently in senior housing to assess the impact of a probiotic yoghurt supplement on small intestinal bacterial overgrowth. Twenty-three participants with positive and thirteen participants with negative hydrogen breath test were studied before and after a period of 4 weeks of probiotic yoghurt administration. Intestinal permeability, plasma endotoxin levels, phagocytic activity of leucocytes, cytokine production by monocytes and free radical response of neutrophils were determined. Intestinal permeability was similar for the two groups and was unaffected by probiotic treatment. Both plasma endotoxin levels and the basal phagocytic activity of leucocytes decreased after yoghurt intake in the two groups. Exposure of monocytes and neutrophils ex vivo led to an increased cytokine response and free radical response, respectively. The normalisation of the various cytokine responses was more apparent in the group with positive breath test. In addition, the plasma levels of lipoplysaccharide binding protein and soluble CD14, lipoplysaccharide pattern recognition receptors and surrogate markers of lipoplysaccharide permeability were diminished by the end of the study. In conclusion, probiotic administration in the elderly normalises the response to endotoxin, and modulates activation markers in blood phagocytes, and therefore may help reduce low-grade chronic inflammation.
KW - Faculty of Science
KW - Immunity
KW - Elderly
KW - Small-intestinal bacterial overgrowth
U2 - 10.1017/S0007114508055591
DO - 10.1017/S0007114508055591
M3 - Journal article
VL - 101
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 7
ER -
ID: 317460027