Development and aging of human spinal cord circuitries
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Development and aging of human spinal cord circuitries. / Geertsen, Svend Sparre; Willerslev-Olsen, Maria; Lorentzen, Jakob; Nielsen, Jens Bo.
In: Journal of Neurophysiology, Vol. 118, No. 2, 2017, p. 1133-1140.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Development and aging of human spinal cord circuitries
AU - Geertsen, Svend Sparre
AU - Willerslev-Olsen, Maria
AU - Lorentzen, Jakob
AU - Nielsen, Jens Bo
N1 - CURIS 2017 NEXS 189
PY - 2017
Y1 - 2017
N2 - The neural motor circuitries in the spinal cord receive information from our senses and the rest of the nervous system and translate it into purposeful movements, which allow us to interact with the rest of the world. In this review, we discuss how these circuitries are established during early development and to what extent they are shaped according to the demands of the body that they control and the environment that the body has to interact with. We also discuss how ageing processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries. The complex, multi-facetted connectivity of the spinal cord motor circuitries allow that they can be used to generate vastly different movements and that their activity can be adapted to meet new challenges imposed by bodily changes or a changing environment. There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.
AB - The neural motor circuitries in the spinal cord receive information from our senses and the rest of the nervous system and translate it into purposeful movements, which allow us to interact with the rest of the world. In this review, we discuss how these circuitries are established during early development and to what extent they are shaped according to the demands of the body that they control and the environment that the body has to interact with. We also discuss how ageing processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries. The complex, multi-facetted connectivity of the spinal cord motor circuitries allow that they can be used to generate vastly different movements and that their activity can be adapted to meet new challenges imposed by bodily changes or a changing environment. There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.
KW - Faculty of Science
KW - Spinal cord
KW - Reflexes
KW - Aging
KW - Motor control
KW - Development
U2 - 10.1152/jn.00103.2017
DO - 10.1152/jn.00103.2017
M3 - Review
C2 - 28566459
VL - 118
SP - 1133
EP - 1140
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 2
ER -
ID: 178842767