Analysis of VUS reporting, variant reinterpretation and recontact policies in clinical genomic sequencing consent forms
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Analysis of VUS reporting, variant reinterpretation and recontact policies in clinical genomic sequencing consent forms. / Vears, Danya F.; Niemiec, Emilia; Howard, Heidi Carmen; Borry, Pascal.
In: European Journal of Human Genetics, Vol. 26, No. 12, 01.12.2018, p. 1743-1751.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Analysis of VUS reporting, variant reinterpretation and recontact policies in clinical genomic sequencing consent forms
AU - Vears, Danya F.
AU - Niemiec, Emilia
AU - Howard, Heidi Carmen
AU - Borry, Pascal
N1 - Funding Information: Acknowledgements D.F.V. is a Postdoctoral Research Fellow of the Research Foundation - Flanders (FWO-Vlaanderen). E.N. has been supported by Erasmus Plus Joint International PhD Programme in Law, Science and Technology Fellowship. This work was facilitated by the COST Action IS1303 ‘Citizen’s Health through public-private Initiatives: Public health, Market and Ethical perspectives’, supported by COST (European Cooperation in Science and Technology) (http:// www.cost.eu). Part of this work has been supported by the SIENNA project, (under grant agreement No 741716) and the BBMRI-ERIC. Publisher Copyright: © 2018, European Society of Human Genetics.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - There are several key unsolved issues relating to the clinical use of next generation sequencing, such as: should laboratories report variants of uncertain significance (VUS) to clinicians and/or patients? Should they reinterpret VUS in response to growing knowledge in the field? And should patients be recontacted regarding such results? We systematically analyzed 58 consent forms in English used in the diagnostic context to investigate their policies for (a) reporting VUS, (b) reinterpreting variants, including who should initiate this, and (c) recontacting patients and the mechanisms for undertaking any recontact. One-third (20/58) of the forms did not mention VUS in any way. Of the 38 forms that mentioned VUS, only half provided some description of what a VUS is. Approximately one-third of forms explicitly stated that reinterpretation of variants for clinical purposes may occur. Less than half mentioned recontact for clinical purposes, with variation as to whether laboratories, patients, or clinicians should initiate this. We suggest that the variability in variant reporting, reinterpretation, and recontact policies and practices revealed by our analysis may lead to diffused responsibility, which could result in missed opportunities for patients or family members to receive a diagnosis in response to updated variant classifications. Finally, we provide some suggestions for ethically appropriate inclusion of policies for reporting VUS, reinterpretation, and recontact on consent forms.
AB - There are several key unsolved issues relating to the clinical use of next generation sequencing, such as: should laboratories report variants of uncertain significance (VUS) to clinicians and/or patients? Should they reinterpret VUS in response to growing knowledge in the field? And should patients be recontacted regarding such results? We systematically analyzed 58 consent forms in English used in the diagnostic context to investigate their policies for (a) reporting VUS, (b) reinterpreting variants, including who should initiate this, and (c) recontacting patients and the mechanisms for undertaking any recontact. One-third (20/58) of the forms did not mention VUS in any way. Of the 38 forms that mentioned VUS, only half provided some description of what a VUS is. Approximately one-third of forms explicitly stated that reinterpretation of variants for clinical purposes may occur. Less than half mentioned recontact for clinical purposes, with variation as to whether laboratories, patients, or clinicians should initiate this. We suggest that the variability in variant reporting, reinterpretation, and recontact policies and practices revealed by our analysis may lead to diffused responsibility, which could result in missed opportunities for patients or family members to receive a diagnosis in response to updated variant classifications. Finally, we provide some suggestions for ethically appropriate inclusion of policies for reporting VUS, reinterpretation, and recontact on consent forms.
UR - http://www.scopus.com/inward/record.url?scp=85052939503&partnerID=8YFLogxK
U2 - 10.1038/s41431-018-0239-7
DO - 10.1038/s41431-018-0239-7
M3 - Journal article
C2 - 30143804
AN - SCOPUS:85052939503
VL - 26
SP - 1743
EP - 1751
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 12
ER -
ID: 369541474