Is reducing appetite beneficial for body weight management in the context of overweight and obesity? A systematic review and meta‐analysis from clinical trials assessing body weight management after exposure to satiety enhancing and/or hunger reducing products
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Is reducing appetite beneficial for body weight management in the context of overweight and obesity? A systematic review and meta‐analysis from clinical trials assessing body weight management after exposure to satiety enhancing and/or hunger reducing products. / Hansen, Thea Toft; Andersen, Sarah Vold; Astrup, Arne; Blundell, John E; Sjödin, Anders Mikael.
I: Obesity Reviews, Bind 20, Nr. 7, 2019, s. 983-997.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Is reducing appetite beneficial for body weight management in the context of overweight and obesity? A systematic review and meta‐analysis from clinical trials assessing body weight management after exposure to satiety enhancing and/or hunger reducing products
AU - Hansen, Thea Toft
AU - Andersen, Sarah Vold
AU - Astrup, Arne
AU - Blundell, John E
AU - Sjödin, Anders Mikael
N1 - CURIS 2019 NEXS 113
PY - 2019
Y1 - 2019
N2 - This review aims to investigate whether interventions that enhance satiety and/or reduce hunger lead to beneficial effects on body weight management in the context of overweight and obesity. A comprehensive review protocol was prepared before conducting a systematic search in PubMed identifying 517 papers with 12 meeting the inclusion criteria. A thorough risk of bias assessment was performed based on the Cochrane collaboration's tool for assessing risk of bias. Based on a meta‐analysis, the average of 75 subjects exposed to satiety enhancing and/or hunger reducing foods during more than 8 weeks coincidently reduced their body weight by 3.60 (1.05; 6.15) kg (mean (95% confidence interval)) more compared with controls. Two studies analysed whether individual reductions in appetite were associated with body weight. Decreased ad libitum energy intake after exposure to the satiety enhancing and/or hunger reducing interventions explained 58% (P < 0.001) and 23% (P < 0.001) of the variations in the subsequent weight losses over 12 and 8 weeks, respectively. Robust acute effects on appetite were found equally likely to be linked to improved body weight management as sustained effects. Satiety enhancing and/or hunger reducing interventions are supported to improve body weight management, but studies specifically designed to demonstrate a causal link remain needed.
AB - This review aims to investigate whether interventions that enhance satiety and/or reduce hunger lead to beneficial effects on body weight management in the context of overweight and obesity. A comprehensive review protocol was prepared before conducting a systematic search in PubMed identifying 517 papers with 12 meeting the inclusion criteria. A thorough risk of bias assessment was performed based on the Cochrane collaboration's tool for assessing risk of bias. Based on a meta‐analysis, the average of 75 subjects exposed to satiety enhancing and/or hunger reducing foods during more than 8 weeks coincidently reduced their body weight by 3.60 (1.05; 6.15) kg (mean (95% confidence interval)) more compared with controls. Two studies analysed whether individual reductions in appetite were associated with body weight. Decreased ad libitum energy intake after exposure to the satiety enhancing and/or hunger reducing interventions explained 58% (P < 0.001) and 23% (P < 0.001) of the variations in the subsequent weight losses over 12 and 8 weeks, respectively. Robust acute effects on appetite were found equally likely to be linked to improved body weight management as sustained effects. Satiety enhancing and/or hunger reducing interventions are supported to improve body weight management, but studies specifically designed to demonstrate a causal link remain needed.
KW - Faculty of Science
KW - Body weight control
KW - Food innovation
KW - Hunger
KW - Satiety
KW - Weight loss
U2 - 10.1111/obr.12854
DO - 10.1111/obr.12854
M3 - Review
C2 - 30945414
VL - 20
SP - 983
EP - 997
JO - Obesity Reviews
JF - Obesity Reviews
SN - 1467-7881
IS - 7
ER -
ID: 215977276