Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study
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Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention : A PREVIEW sub-study. / Møller, Grith; Andersen, Jens Rikardt; Ritz, Christian; Silvestre, Marta P; Navas-Carretero, Santiago; Jalo, Elli; Christensen, Pia; Simpson, Elizabeth M; Taylor, Moira A; Martinez, J Alfredo; Macdonald, Ian; Swindell, Nils; Mackintosh, Kelly; Stratton, Gareth; Fogelholm, Mikael; Larsen, Thomas Meinert; Poppitt, Sally D; Dragsted, Lars Ove; Raben, Anne.
I: Nutrients, Bind 54, 54, 09.01.2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention
T2 - A PREVIEW sub-study
AU - Møller, Grith
AU - Andersen, Jens Rikardt
AU - Ritz, Christian
AU - Silvestre, Marta P
AU - Navas-Carretero, Santiago
AU - Jalo, Elli
AU - Christensen, Pia
AU - Simpson, Elizabeth M
AU - Taylor, Moira A
AU - Martinez, J Alfredo
AU - Macdonald, Ian
AU - Swindell, Nils
AU - Mackintosh, Kelly
AU - Stratton, Gareth
AU - Fogelholm, Mikael
AU - Larsen, Thomas Meinert
AU - Poppitt, Sally D
AU - Dragsted, Lars Ove
AU - Raben, Anne
N1 - CURIS 2018 NEXS 021
PY - 2018/1/9
Y1 - 2018/1/9
N2 - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.
AB - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.
KW - Faculty of Science
KW - Pre-diabetes
KW - Dietary protein
KW - Creatinine clearance
KW - Glomerular filtration rate
KW - Albumin
KW - Urea
U2 - 10.3390/nu10010054
DO - 10.3390/nu10010054
M3 - Journal article
C2 - 29315212
VL - 54
JO - Nutrients
JF - Nutrients
SN - 2072-6643
M1 - 54
ER -
ID: 188161183