Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study
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Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study. / Myhrstad, Mari C W; de Mello, Vanessa D; Dahlman, Ingrid; Kolehmainen, Marjukka; Paananen, Jussi; Rundblad, Amanda; Carlberg, Carsten; Olstad, Ole Kristoffer; Pihlajamäki, Jussi; Holven, Kirsten B; Hermansen, Kjeld; Dragsted, Lars Ove; Gunnarsdottir, Ingibjörg; Cloetens, Lieselotte; Storm, Matilda Ulmius; Åkesson, Björn; Rosqvist, Fredrik; Hukkanen, Janne; Herzig, Karl-Heinz; Risérus, Ulf; Thorsdottir, Inga; Poutanen, Kaisa S; Savolainen, Markku J; Schwab, Ursula; Arner, Peter; Uusitupa, Matti; Ulven, Stine M.
In: Molecular Nutrition & Food Research, Vol. 63, No. 13, 1801405, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study
AU - Myhrstad, Mari C W
AU - de Mello, Vanessa D
AU - Dahlman, Ingrid
AU - Kolehmainen, Marjukka
AU - Paananen, Jussi
AU - Rundblad, Amanda
AU - Carlberg, Carsten
AU - Olstad, Ole Kristoffer
AU - Pihlajamäki, Jussi
AU - Holven, Kirsten B
AU - Hermansen, Kjeld
AU - Dragsted, Lars Ove
AU - Gunnarsdottir, Ingibjörg
AU - Cloetens, Lieselotte
AU - Storm, Matilda Ulmius
AU - Åkesson, Björn
AU - Rosqvist, Fredrik
AU - Hukkanen, Janne
AU - Herzig, Karl-Heinz
AU - Risérus, Ulf
AU - Thorsdottir, Inga
AU - Poutanen, Kaisa S
AU - Savolainen, Markku J
AU - Schwab, Ursula
AU - Arner, Peter
AU - Uusitupa, Matti
AU - Ulven, Stine M
N1 - CURIS 2019 NEXS 133 This article is protected by copyright. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with the metabolic syndrome.Methods and Results: Subjects with the metabolic syndrome underwent an 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants were included. PBMCs were obtained before and after intervention and total RNA was subjected to global transcriptome analysis. 1302 probe sets were differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these were significantly regulated (FDR q-value < 0.25) and were mainly involved in mitochondrial function, cell growth and cell adhesion. The list of 1302 regulated probe sets was subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response and cell cycle were down-regulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors including NFR1, NFR2 and NF-κB, were down-regulated in the healthy Nordic diet group.Conclusion: These results suggests that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation. This article is protected by copyright. All rights reserved.
AB - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with the metabolic syndrome.Methods and Results: Subjects with the metabolic syndrome underwent an 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants were included. PBMCs were obtained before and after intervention and total RNA was subjected to global transcriptome analysis. 1302 probe sets were differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these were significantly regulated (FDR q-value < 0.25) and were mainly involved in mitochondrial function, cell growth and cell adhesion. The list of 1302 regulated probe sets was subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response and cell cycle were down-regulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors including NFR1, NFR2 and NF-κB, were down-regulated in the healthy Nordic diet group.Conclusion: These results suggests that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Healthy Nordic diet
KW - Metabolic syndrome
KW - PBMCs
KW - Transcriptome
KW - Gene-expression
U2 - 10.1002/mnfr.201801405
DO - 10.1002/mnfr.201801405
M3 - Journal article
C2 - 30964598
VL - 63
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
SN - 1613-4125
IS - 13
M1 - 1801405
ER -
ID: 216460579