Gut microbiota alterations and dietary modulation in childhood malnutrition - The role of short chain fatty acids
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Gut microbiota alterations and dietary modulation in childhood malnutrition - The role of short chain fatty acids. / Pekmez, Ceyda Tugba; Dragsted, Lars Ove; Brahe, Lena Kirchner.
In: Clinical Nutrition, Vol. 38, No. 2, 2019, p. 615-630.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Gut microbiota alterations and dietary modulation in childhood malnutrition - The role of short chain fatty acids
AU - Pekmez, Ceyda Tugba
AU - Dragsted, Lars Ove
AU - Brahe, Lena Kirchner
N1 - CURIS 2019 NEXS 108
PY - 2019
Y1 - 2019
N2 - The gut microbiome affects the health status of the host through different mechanisms and is associated with a wide variety of diseases. Both childhood undernutrition and obesity are linked to alterations in composition and functionality of the gut microbiome. One of the possible mechanisms underlying the interplay between microbiota and host metabolism is through appetite-regulating hormones (including leptin, ghrelin, glucagon-like peptide-1). Short chain fatty acids, the end product of bacterial fermentation of non-digestible carbohydrates, might be able to alter energy harvest and metabolism through enteroendocrine cell signaling, adipogenesis and insulin-like growth factor-1 production. Elucidating these mechanisms may lead to development of new modulation practices of the gut microbiota as a potential prevention and treatment strategy for childhood malnutrition. The present overview will briefly outline the gut microbiota development in the early life, gut microbiota alterations in childhood undernutrition and obesity, and whether this relationship is causal. Further we will discuss possible underlying mechanisms in relation to the gut-brain axis and short chain fatty acids, and the potential of probiotics, prebiotics and synbiotics for modulating the gut microbiota during childhood as a prevention and treatment strategy against undernutrition and obesity.
AB - The gut microbiome affects the health status of the host through different mechanisms and is associated with a wide variety of diseases. Both childhood undernutrition and obesity are linked to alterations in composition and functionality of the gut microbiome. One of the possible mechanisms underlying the interplay between microbiota and host metabolism is through appetite-regulating hormones (including leptin, ghrelin, glucagon-like peptide-1). Short chain fatty acids, the end product of bacterial fermentation of non-digestible carbohydrates, might be able to alter energy harvest and metabolism through enteroendocrine cell signaling, adipogenesis and insulin-like growth factor-1 production. Elucidating these mechanisms may lead to development of new modulation practices of the gut microbiota as a potential prevention and treatment strategy for childhood malnutrition. The present overview will briefly outline the gut microbiota development in the early life, gut microbiota alterations in childhood undernutrition and obesity, and whether this relationship is causal. Further we will discuss possible underlying mechanisms in relation to the gut-brain axis and short chain fatty acids, and the potential of probiotics, prebiotics and synbiotics for modulating the gut microbiota during childhood as a prevention and treatment strategy against undernutrition and obesity.
KW - Faculty of Science
KW - Gut-brain axis
KW - Gut peptides
KW - Obesity
KW - Prebiotics
KW - Probiotics
KW - Synbiotics
U2 - 10.1016/j.clnu.2018.02.014
DO - 10.1016/j.clnu.2018.02.014
M3 - Review
C2 - 29496274
VL - 38
SP - 615
EP - 630
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 2
ER -
ID: 191898701