Hypoxic training improves normoxic glucose tolerance in adolescents with obesity
Research output: Contribution to journal › Journal article › Research › peer-review
Purpose: This study aimed to test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity.
Methods: Fourteen adolescents with obesity were assigned to 6 wk of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained three times per week for 50-60 min, including endurance and resistance exercises. Oral glucose tolerance test, blood and morphological analyses, and physical performance tests were performed before and after the training period.
Results: After training, hypoxia, but not normoxia, decreased the area under the curve of plasma insulin (-49%; P = 0.001) and glucose levels (-14%; P = 0.005) during oral glucose tolerance test. Decreased plasma triglycerides levels (P = 0.03) and increased maximal aerobic power (P = 0.002), work capacity at 160 bpm (P = 0.002), and carbohydrate consumption during exercise (P = 0.03) were measured only in the hypoxic group.
Conclusions: Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
Original language | English |
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Journal | Medicine and Science in Sports and Exercise |
Volume | 50 |
Issue number | 11 |
Pages (from-to) | 2200-2208 |
Number of pages | 9 |
ISSN | 0195-9131 |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
- Faculty of Science - Insulin resistance, Hypoxia, Physical activity, Glucose metabolism
Research areas
ID: 214128634