Novel Mechanisms in mTORC1-regulated Muscle Plasticity
Research output: Book/Report › Ph.D. thesis › Research
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Novel Mechanisms in mTORC1-regulated Muscle Plasticity. / Madsen, Agnete Louise Bjerregaard.
Copenhagen : Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2018. 87 p.Research output: Book/Report › Ph.D. thesis › Research
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TY - BOOK
T1 - Novel Mechanisms in mTORC1-regulated Muscle Plasticity
AU - Madsen, Agnete Louise Bjerregaard
N1 - CURIS 2018 NEXS 413
PY - 2018
Y1 - 2018
N2 - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.
AB - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.
KW - Faculty of Science
KW - mTORC1
KW - AMPK
KW - ULK1
KW - Autophagy
KW - Skeletal muscle
KW - Muscle plasticity
KW - Molecular mechanisms
KW - Cross-talk between anabolic and catabolic signalling pathways
KW - Physical activity
UR - https://soeg.kb.dk/permalink/45KBDK_KGL/1pioq0f/alma99122845724305763
M3 - Ph.D. thesis
SN - 978-87-7209-211-9
BT - Novel Mechanisms in mTORC1-regulated Muscle Plasticity
PB - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
CY - Copenhagen
ER -
ID: 209385689