Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only. / Lauritzen, Lotte; Eriksen, S E; Hjorth, Mads Fiil; Nielsen, Maria Søgaard; Olsen, Sjurdur F.; Stark, K D; Michaelsen, Kim F.; Damsgaard, Camilla Trab.
In: The British Journal of Nutrition, Vol. 116, No. 12, 2016, p. 2082-2090.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only
AU - Lauritzen, Lotte
AU - Eriksen, S E
AU - Hjorth, Mads Fiil
AU - Nielsen, Maria Søgaard
AU - Olsen, Sjurdur F.
AU - Stark, K D
AU - Michaelsen, Kim F.
AU - Damsgaard, Camilla Trab
N1 - CURIS 2016 NEXS 383
PY - 2016
Y1 - 2016
N2 - Dietary long-chain n-3 PUFA (n-3 LCPUFA) in infancy may have long-term effects on lifestyle disease risk. The present follow-up study investigated whether maternal fish oil (FO) supplementation during lactation affected growth and blood pressure in adolescents and whether the effects differed between boys and girls. Mother-infant pairs (n 103) completed a randomised controlled trial with FO (1·5 g/d n-3 LCPUFA) or olive oil (OO) supplements during the first 4 months of lactation; forty-seven mother-infant pairs with high fish intake were followed-up for 4 months as the reference group. We also followed-up 100 children with assessment of growth, blood pressure, diet by FFQ and physical activity by 7-d accelerometry at 13·5 (sd 0·4) years of age. Dried whole-blood fatty acid composition was analysed in a subgroup (n 49). At 13 years of age, whole-blood n-3 LCPUFA, diet, physical activity and body composition did not differ between the three groups. The children from the FO group were 3·4 (95 % CI 0·2, 6·6) cm shorter (P=0·035) than those from the OO group, and tended to have less advanced puberty (P=0·068), which explained the difference in height. There was a sex-specific effect on diastolic blood pressure (P sex×group=0·020), which was driven by a 3·9 (95 % CI 0·2, 7·5) mmHg higher diastolic blood pressure in the FO compared with the OO group among boys only (P=0·041). Our results indicate that early n-3 LCPUFA intake may reduce height in early adolescence due to a delay in pubertal maturation and increase blood pressure specifically in boys, thereby tending to counteract existing sex differences.
AB - Dietary long-chain n-3 PUFA (n-3 LCPUFA) in infancy may have long-term effects on lifestyle disease risk. The present follow-up study investigated whether maternal fish oil (FO) supplementation during lactation affected growth and blood pressure in adolescents and whether the effects differed between boys and girls. Mother-infant pairs (n 103) completed a randomised controlled trial with FO (1·5 g/d n-3 LCPUFA) or olive oil (OO) supplements during the first 4 months of lactation; forty-seven mother-infant pairs with high fish intake were followed-up for 4 months as the reference group. We also followed-up 100 children with assessment of growth, blood pressure, diet by FFQ and physical activity by 7-d accelerometry at 13·5 (sd 0·4) years of age. Dried whole-blood fatty acid composition was analysed in a subgroup (n 49). At 13 years of age, whole-blood n-3 LCPUFA, diet, physical activity and body composition did not differ between the three groups. The children from the FO group were 3·4 (95 % CI 0·2, 6·6) cm shorter (P=0·035) than those from the OO group, and tended to have less advanced puberty (P=0·068), which explained the difference in height. There was a sex-specific effect on diastolic blood pressure (P sex×group=0·020), which was driven by a 3·9 (95 % CI 0·2, 7·5) mmHg higher diastolic blood pressure in the FO compared with the OO group among boys only (P=0·041). Our results indicate that early n-3 LCPUFA intake may reduce height in early adolescence due to a delay in pubertal maturation and increase blood pressure specifically in boys, thereby tending to counteract existing sex differences.
KW - Faculty of Science
KW - n-3 long-chain PUFA
KW - Puberty
KW - Growth
KW - Programming
KW - Health
U2 - 10.1017/S0007114516004293
DO - 10.1017/S0007114516004293
M3 - Journal article
C2 - 28065179
VL - 116
SP - 2082
EP - 2090
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 12
ER -
ID: 172095423