Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease
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Background: In inflammatory bowel disease a defective mucosal barrier, a dysregulated
immune response and an excessive reactivity against the gut microbiota are assumed to cause
a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam
treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction
of both the intestinal barrier and the immune system. However, the translational value of this
model has not been thoroughly clarified.
Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to
clinical features, pathogenic mechanisms and its ability to respond to existing therapies.
Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical
manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40
treatment were assessed.
immune response and an excessive reactivity against the gut microbiota are assumed to cause
a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam
treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction
of both the intestinal barrier and the immune system. However, the translational value of this
model has not been thoroughly clarified.
Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to
clinical features, pathogenic mechanisms and its ability to respond to existing therapies.
Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical
manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40
treatment were assessed.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Crohn's and Colitis |
Vol/bind | 8 |
Udgave nummer | 2 |
Sider (fra-til) | 147-160 |
Antal sider | 14 |
ISSN | 1873-9946 |
DOI | |
Status | Udgivet - 2014 |
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ID: 68162694