The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

Research output: Contribution to journal › Journal article › Research › peer-review

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The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. / Nestvogel, Dennis B; Merino, Ricardo Martins; Leon-Pinzon, Carolina; Schottdorf, Manuel; Lee, ChoongKu; Imig, Cordelia; Brose, Nils; Rhee, Jeong-Seop.

In: Cell Reports, Vol. 30, No. 10, 10.03.2020, p. 3261-3269.e4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nestvogel, DB, Merino, RM, Leon-Pinzon, C, Schottdorf, M, Lee, C, Imig, C, Brose, N & Rhee, J-S 2020, 'The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex', Cell Reports, vol. 30, no. 10, pp. 3261-3269.e4. https://doi.org/10.1016/j.celrep.2020.02.045

APA

Nestvogel, D. B., Merino, R. M., Leon-Pinzon, C., Schottdorf, M., Lee, C., Imig, C., Brose, N., & Rhee, J-S. (2020). The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. Cell Reports, 30(10), 3261-3269.e4. https://doi.org/10.1016/j.celrep.2020.02.045

Vancouver

Nestvogel DB, Merino RM, Leon-Pinzon C, Schottdorf M, Lee C, Imig C et al. The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. Cell Reports. 2020 Mar 10;30(10):3261-3269.e4. https://doi.org/10.1016/j.celrep.2020.02.045

Author

Nestvogel, Dennis B ; Merino, Ricardo Martins ; Leon-Pinzon, Carolina ; Schottdorf, Manuel ; Lee, ChoongKu ; Imig, Cordelia ; Brose, Nils ; Rhee, Jeong-Seop. / The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. In: Cell Reports. 2020 ; Vol. 30, No. 10. pp. 3261-3269.e4.

Bibtex

@article{f2f9e6fa71f94c36afa4fb153daa70ff,

title = "The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex",

abstract = "Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS and Munc13 families to shape short-term plasticity in vitro, but the relevance of this phenomenon for information processing in the intact brain is unknown. By combining sensory stimulation with in vivo patch-clamp recordings in anesthetized mice, we show that genetic deletion of CAPS-1 in thalamic neurons results in more rapid adaptation of sensory-evoked subthreshold responses in layer 4 neurons of the primary visual cortex. Optogenetic experiments in acute brain slices further reveal that the enhanced adaptation is caused by more pronounced short-term synaptic depression. Our data indicate that neurons engage CAPS-family priming proteins to shape short-term plasticity for optimal sensory information transfer between thalamic and cortical neurons in the intact brain in vivo.",

author = "Nestvogel, {Dennis B} and Merino, {Ricardo Martins} and Carolina Leon-Pinzon and Manuel Schottdorf and ChoongKu Lee and Cordelia Imig and Nils Brose and Jeong-Seop Rhee",

year = "2020",

month = mar,

day = "10",

doi = "10.1016/j.celrep.2020.02.045",

language = "English",

volume = "30",

pages = "3261--3269.e4",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "10",

}

RIS

TY - JOUR

T1 - The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

AU - Nestvogel, Dennis B

AU - Merino, Ricardo Martins

AU - Leon-Pinzon, Carolina

AU - Schottdorf, Manuel

AU - Lee, ChoongKu

AU - Imig, Cordelia

AU - Brose, Nils

AU - Rhee, Jeong-Seop

PY - 2020/3/10

Y1 - 2020/3/10

N2 - Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS and Munc13 families to shape short-term plasticity in vitro, but the relevance of this phenomenon for information processing in the intact brain is unknown. By combining sensory stimulation with in vivo patch-clamp recordings in anesthetized mice, we show that genetic deletion of CAPS-1 in thalamic neurons results in more rapid adaptation of sensory-evoked subthreshold responses in layer 4 neurons of the primary visual cortex. Optogenetic experiments in acute brain slices further reveal that the enhanced adaptation is caused by more pronounced short-term synaptic depression. Our data indicate that neurons engage CAPS-family priming proteins to shape short-term plasticity for optimal sensory information transfer between thalamic and cortical neurons in the intact brain in vivo.

AB - Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS and Munc13 families to shape short-term plasticity in vitro, but the relevance of this phenomenon for information processing in the intact brain is unknown. By combining sensory stimulation with in vivo patch-clamp recordings in anesthetized mice, we show that genetic deletion of CAPS-1 in thalamic neurons results in more rapid adaptation of sensory-evoked subthreshold responses in layer 4 neurons of the primary visual cortex. Optogenetic experiments in acute brain slices further reveal that the enhanced adaptation is caused by more pronounced short-term synaptic depression. Our data indicate that neurons engage CAPS-family priming proteins to shape short-term plasticity for optimal sensory information transfer between thalamic and cortical neurons in the intact brain in vivo.

U2 - 10.1016/j.celrep.2020.02.045

DO - 10.1016/j.celrep.2020.02.045

M3 - Journal article

C2 - 32160535

VL - 30

SP - 3261-3269.e4

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 10

ER -

ID: 237696628

Faculty of Law