The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

Research output: Contribution to journalJournal articlepeer-review

  • Dennis B Nestvogel
  • Ricardo Martins Merino
  • Carolina Leon-Pinzon
  • Manuel Schottdorf
  • ChoongKu Lee
  • Imig, Cordelia
  • Nils Brose
  • Jeong-Seop Rhee

Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS and Munc13 families to shape short-term plasticity in vitro, but the relevance of this phenomenon for information processing in the intact brain is unknown. By combining sensory stimulation with in vivo patch-clamp recordings in anesthetized mice, we show that genetic deletion of CAPS-1 in thalamic neurons results in more rapid adaptation of sensory-evoked subthreshold responses in layer 4 neurons of the primary visual cortex. Optogenetic experiments in acute brain slices further reveal that the enhanced adaptation is caused by more pronounced short-term synaptic depression. Our data indicate that neurons engage CAPS-family priming proteins to shape short-term plasticity for optimal sensory information transfer between thalamic and cortical neurons in the intact brain in vivo.

Original languageEnglish
JournalCell Reports
Volume30
Issue number10
Pages (from-to)3261-3269.e4
ISSN2211-1247
DOIs
Publication statusPublished - 10 Mar 2020
Externally publishedYes

Bibliographical note

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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