Supplemental folic acid in pregnancy and childhood cancer risk
Research output: Contribution to journal › Journal article › Research › peer-review
Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.
Original language | English |
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Journal | British Journal of Cancer |
Volume | 114 |
Pages (from-to) | 71-75 |
Number of pages | 5 |
ISSN | 0007-0920 |
DOIs | |
Publication status | Published - 2016 |
- childhood cancer, cohort study, folic acid supplementation, pregnancy
Research areas
ID: 179218634