Supplemental folic acid in pregnancy and childhood cancer risk

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Supplemental folic acid in pregnancy and childhood cancer risk. / Mortensen, Jan Helge Seglem; Øyen, Nina; Fomina, Tatiana; Melbye, Mads; Tretli, Steinar; Vollset, Stein Emil; Bjørge, Tone.

In: British Journal of Cancer, Vol. 114, 2016, p. 71-75.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mortensen, JHS, Øyen, N, Fomina, T, Melbye, M, Tretli, S, Vollset, SE & Bjørge, T 2016, 'Supplemental folic acid in pregnancy and childhood cancer risk', British Journal of Cancer, vol. 114, pp. 71-75. https://doi.org/10.1038/bjc.2015.446

APA

Mortensen, J. H. S., Øyen, N., Fomina, T., Melbye, M., Tretli, S., Vollset, S. E., & Bjørge, T. (2016). Supplemental folic acid in pregnancy and childhood cancer risk. British Journal of Cancer, 114, 71-75. https://doi.org/10.1038/bjc.2015.446

Vancouver

Mortensen JHS, Øyen N, Fomina T, Melbye M, Tretli S, Vollset SE et al. Supplemental folic acid in pregnancy and childhood cancer risk. British Journal of Cancer. 2016;114:71-75. https://doi.org/10.1038/bjc.2015.446

Author

Mortensen, Jan Helge Seglem ; Øyen, Nina ; Fomina, Tatiana ; Melbye, Mads ; Tretli, Steinar ; Vollset, Stein Emil ; Bjørge, Tone. / Supplemental folic acid in pregnancy and childhood cancer risk. In: British Journal of Cancer. 2016 ; Vol. 114. pp. 71-75.

Bibtex

@article{966a40f3c4c347b5bb8032ba0826eba5,
title = "Supplemental folic acid in pregnancy and childhood cancer risk",
abstract = "Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.",
keywords = "childhood cancer, cohort study, folic acid supplementation, pregnancy",
author = "Mortensen, {Jan Helge Seglem} and Nina {\O}yen and Tatiana Fomina and Mads Melbye and Steinar Tretli and Vollset, {Stein Emil} and Tone Bj{\o}rge",
year = "2016",
doi = "10.1038/bjc.2015.446",
language = "English",
volume = "114",
pages = "71--75",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Supplemental folic acid in pregnancy and childhood cancer risk

AU - Mortensen, Jan Helge Seglem

AU - Øyen, Nina

AU - Fomina, Tatiana

AU - Melbye, Mads

AU - Tretli, Steinar

AU - Vollset, Stein Emil

AU - Bjørge, Tone

PY - 2016

Y1 - 2016

N2 - Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.

AB - Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.

KW - childhood cancer

KW - cohort study

KW - folic acid supplementation

KW - pregnancy

U2 - 10.1038/bjc.2015.446

DO - 10.1038/bjc.2015.446

M3 - Journal article

C2 - 26757423

AN - SCOPUS:84954349446

VL - 114

SP - 71

EP - 75

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

ER -

ID: 179218634