Ginkgolides: selective acetylations, translactonization, and biological evaluation
Research output: Contribution to journal › Journal article › Research › peer-review
Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.
| Original language | English |
|---|---|
| Journal | Journal of Organic Chemistry |
| Volume | 67 |
| Issue number | 13 |
| Pages (from-to) | 4623-4626 |
| Number of pages | 4 |
| ISSN | 0022-3263 |
| DOIs | |
| Publication status | Published - 28 Jun 2002 |
| Externally published | Yes |
- Acetates, Binding, Competitive, Catalysis, Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Ligands, Photoaffinity Labels, Platelet Activating Factor, Structure-Activity Relationship
Research areas
ID: 45810405