Ginkgolides: selective acetylations, translactonization, and biological evaluation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ginkgolides : selective acetylations, translactonization, and biological evaluation. / Jaracz, Stanislav; Strømgaard, Kristian; Nakanishi, Koji.

In: Journal of Organic Chemistry, Vol. 67, No. 13, 28.06.2002, p. 4623-4626.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jaracz, S, Strømgaard, K & Nakanishi, K 2002, 'Ginkgolides: selective acetylations, translactonization, and biological evaluation', Journal of Organic Chemistry, vol. 67, no. 13, pp. 4623-4626. https://doi.org/10.1021/jo020139n

APA

Jaracz, S., Strømgaard, K., & Nakanishi, K. (2002). Ginkgolides: selective acetylations, translactonization, and biological evaluation. Journal of Organic Chemistry, 67(13), 4623-4626. https://doi.org/10.1021/jo020139n

Vancouver

Jaracz S, Strømgaard K, Nakanishi K. Ginkgolides: selective acetylations, translactonization, and biological evaluation. Journal of Organic Chemistry. 2002 Jun 28;67(13):4623-4626. https://doi.org/10.1021/jo020139n

Author

Jaracz, Stanislav ; Strømgaard, Kristian ; Nakanishi, Koji. / Ginkgolides : selective acetylations, translactonization, and biological evaluation. In: Journal of Organic Chemistry. 2002 ; Vol. 67, No. 13. pp. 4623-4626.

Bibtex

@article{34e8a5d237644377be3a19913d003d92,
title = "Ginkgolides: selective acetylations, translactonization, and biological evaluation",
abstract = "Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.",
keywords = "Acetates, Binding, Competitive, Catalysis, Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Ligands, Photoaffinity Labels, Platelet Activating Factor, Structure-Activity Relationship",
author = "Stanislav Jaracz and Kristian Str{\o}mgaard and Koji Nakanishi",
year = "2002",
month = jun,
day = "28",
doi = "10.1021/jo020139n",
language = "English",
volume = "67",
pages = "4623--4626",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "13",

}

RIS

TY - JOUR

T1 - Ginkgolides

T2 - selective acetylations, translactonization, and biological evaluation

AU - Jaracz, Stanislav

AU - Strømgaard, Kristian

AU - Nakanishi, Koji

PY - 2002/6/28

Y1 - 2002/6/28

N2 - Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.

AB - Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.

KW - Acetates

KW - Binding, Competitive

KW - Catalysis

KW - Diterpenes

KW - Ginkgo biloba

KW - Ginkgolides

KW - Lactones

KW - Ligands

KW - Photoaffinity Labels

KW - Platelet Activating Factor

KW - Structure-Activity Relationship

U2 - 10.1021/jo020139n

DO - 10.1021/jo020139n

M3 - Journal article

C2 - 12076171

VL - 67

SP - 4623

EP - 4626

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 13

ER -

ID: 45810405