Temocene: the porphycene analogue of temoporfin (Foscan®)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Temocene: the porphycene analogue of temoporfin (Foscan®). / Garcia-Diaz, Maria; Sanchez-Garcia, David; Nonell, Santi; Soriano, Jorge; Villanueva, Angeles; Stockert, Juan Carlos; Canete, Magdalena; Sagrista, Maria Lluisa; Mora, Margarita.
I: MedChemComm, Bind 2, Nr. 7, 01.07.2011, s. 616-619.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temocene: the porphycene analogue of temoporfin (Foscan®)
AU - Garcia-Diaz, Maria
AU - Sanchez-Garcia, David
AU - Nonell, Santi
AU - Soriano, Jorge
AU - Villanueva, Angeles
AU - Stockert, Juan Carlos
AU - Canete, Magdalena
AU - Sagrista, Maria Lluisa
AU - Mora, Margarita
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.
AB - Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.
KW - Former Faculty of Pharmaceutical Sciences
UR - http://www.scopus.com/inward/record.url?scp=79960157980&partnerID=8YFLogxK
U2 - 10.1039/c1md00065a
DO - 10.1039/c1md00065a
M3 - Journal article
AN - SCOPUS:79960157980
VL - 2
SP - 616
EP - 619
JO - MedChemComm
JF - MedChemComm
SN - 2040-2503
IS - 7
ER -
ID: 46457104