Research has suggested that lesbian, gay and bisexual (LGB) individuals are more likely to smoke tobacco than heterosexual individuals, but specific geographic patterns have not been examined frequently. We analysed change in smoking prevalence over time across Great Britain for LGB and heterosexual populations, comparing models for men and women. Smoking prevalence remained greater for sexual minority (SM) women over time than for other groups. Across Great Britain, decreases in smoking prevalence in urban areas were more pronounced for SM men compared with SM women. Future anti-smoking policies should consider sexuality and its association with place to eradicate smoking inequalities.