The plasma membrane H+-ATPase, a simple polypeptide with a long history
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The plasma membrane H+-ATPase, a simple polypeptide with a long history. / Palmgren, Michael; Morsomme, Pierre.
In: Yeast, Vol. 36, No. 4, 04.2019, p. 201-210.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The plasma membrane H+-ATPase, a simple polypeptide with a long history
AU - Palmgren, Michael
AU - Morsomme, Pierre
PY - 2019/4
Y1 - 2019/4
N2 - The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.
AB - The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.
KW - Arabidopsis thaliana
KW - F-type ATPase
KW - Neurospora crassa
KW - Nicotiana tabacum
KW - P-type ATPase
KW - proton pump
KW - Saccharomyces cerevisiae
KW - Schizosaccharomyces pombe
U2 - 10.1002/yea.3365
DO - 10.1002/yea.3365
M3 - Journal article
C2 - 30447028
AN - SCOPUS:85058038743
VL - 36
SP - 201
EP - 210
JO - Yeast
JF - Yeast
SN - 0749-503X
IS - 4
ER -
ID: 213856468