The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

Research output: Contribution to journal › Journal article › Research › peer-review

  • Emil List Larsen
  • Lucia Padella
  • Helle Kirstine Mørup Bergholdt
  • Trine Henriksen
  • Lucia Santoro
  • Orazio Gabrielli
  • Poulsen, Henrik Enghusen
  • Gian Paolo Littarru
  • Patrick Orlando
  • Luca Tiano

Elevated levels of oxidative nucleic acid modifications have been proposed to be associated with some of the clinical characteristics of Down syndrome. Oral intake of coenzyme Q10 improves oxidative status and shows a tendency toward protective effect on DNA oxidation in certain age groups of children with Down syndrome. Here, we demonstrate that long-term (i.e., 4 years) treatment with coenzyme Q10 (ubiquinone) at the dosage of 4 mg/kg/d does not affect whole body DNA and RNA oxidation.

Original languageEnglish
JournalNeurobiology of Aging
Volume67
Pages (from-to)159-161
ISSN0197-4580
DOIs
Publication statusPublished - 2018

    Research areas

  • Administration, Oral, Biomarkers/urine, Child, DNA/metabolism, Deoxyadenosines/urine, Down Syndrome/drug therapy, Guanine/analogs & derivatives, Humans, Oxidation-Reduction/drug effects, Oxidative Stress/drug effects, RNA/metabolism, Time Factors, Ubiquinone/administration & dosage

ID: 212907807