The effect of cysteamine on the Brunner gland secretion in the rat

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The effect of cysteamine on the Brunner gland secretion in the rat. / Poulsen, Steen Seier.

In: Scandinavian Journal of Gastroenterology, Vol. 16, No. 1, 1981, p. 93-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS 1981, 'The effect of cysteamine on the Brunner gland secretion in the rat', Scandinavian Journal of Gastroenterology, vol. 16, no. 1, pp. 93-6.

APA

Poulsen, S. S. (1981). The effect of cysteamine on the Brunner gland secretion in the rat. Scandinavian Journal of Gastroenterology, 16(1), 93-6.

Vancouver

Poulsen SS. The effect of cysteamine on the Brunner gland secretion in the rat. Scandinavian Journal of Gastroenterology. 1981;16(1):93-6.

Author

Poulsen, Steen Seier. / The effect of cysteamine on the Brunner gland secretion in the rat. In: Scandinavian Journal of Gastroenterology. 1981 ; Vol. 16, No. 1. pp. 93-6.

Bibtex

@article{ea5a9f966f0f41bdadd9da67cbc4e125,
title = "The effect of cysteamine on the Brunner gland secretion in the rat",
abstract = "Cysteamine in a single subcutaneous administration induces release of gastrin, acid hypersecretion, and duodenal ulcer in rats. Pentagastrin-induced acid hypersecretion has no ulcerogenic effect. The Brunner glands in the proximal duodenum have previously been shown to be an important factor in the natural defence of the duodenal mucosa, and this study has been performed to determine the effect of cysteamine and pentagastrin on the Brunner glands in the rat. The proximal duodenum was isolated in situ and drained by a polyethylene tube. The secretion was studied for two 5-h periods after administration of cysteamine or pentagastrin, and then the Brunner glands were studied histologically. Pentagastrin did not affect spontaneous Brunner gland secretion, whereas cysteamine inhibited the output approximately 50%. After cysteamine the secretory cells were low and depleted of mucus, suggesting that cysteamine interferes with the synthesis of the secretory product. The depression of the Brunner gland secretion may be an important factor in the pathogenesis of cysteamine-induced duodenal ulceration.",
keywords = "Animals, Brunner Glands, Cysteamine, Duodenal Ulcer, Duodenum, Female, Pentagastrin, Rats, Secretory Rate",
author = "Poulsen, {Steen Seier}",
year = "1981",
language = "English",
volume = "16",
pages = "93--6",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of cysteamine on the Brunner gland secretion in the rat

AU - Poulsen, Steen Seier

PY - 1981

Y1 - 1981

N2 - Cysteamine in a single subcutaneous administration induces release of gastrin, acid hypersecretion, and duodenal ulcer in rats. Pentagastrin-induced acid hypersecretion has no ulcerogenic effect. The Brunner glands in the proximal duodenum have previously been shown to be an important factor in the natural defence of the duodenal mucosa, and this study has been performed to determine the effect of cysteamine and pentagastrin on the Brunner glands in the rat. The proximal duodenum was isolated in situ and drained by a polyethylene tube. The secretion was studied for two 5-h periods after administration of cysteamine or pentagastrin, and then the Brunner glands were studied histologically. Pentagastrin did not affect spontaneous Brunner gland secretion, whereas cysteamine inhibited the output approximately 50%. After cysteamine the secretory cells were low and depleted of mucus, suggesting that cysteamine interferes with the synthesis of the secretory product. The depression of the Brunner gland secretion may be an important factor in the pathogenesis of cysteamine-induced duodenal ulceration.

AB - Cysteamine in a single subcutaneous administration induces release of gastrin, acid hypersecretion, and duodenal ulcer in rats. Pentagastrin-induced acid hypersecretion has no ulcerogenic effect. The Brunner glands in the proximal duodenum have previously been shown to be an important factor in the natural defence of the duodenal mucosa, and this study has been performed to determine the effect of cysteamine and pentagastrin on the Brunner glands in the rat. The proximal duodenum was isolated in situ and drained by a polyethylene tube. The secretion was studied for two 5-h periods after administration of cysteamine or pentagastrin, and then the Brunner glands were studied histologically. Pentagastrin did not affect spontaneous Brunner gland secretion, whereas cysteamine inhibited the output approximately 50%. After cysteamine the secretory cells were low and depleted of mucus, suggesting that cysteamine interferes with the synthesis of the secretory product. The depression of the Brunner gland secretion may be an important factor in the pathogenesis of cysteamine-induced duodenal ulceration.

KW - Animals

KW - Brunner Glands

KW - Cysteamine

KW - Duodenal Ulcer

KW - Duodenum

KW - Female

KW - Pentagastrin

KW - Rats

KW - Secretory Rate

M3 - Journal article

C2 - 7233083

VL - 16

SP - 93

EP - 96

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 1

ER -

ID: 47489974