The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. / Ali, H; Christensen, S B; Foreman, J C; Pearce, F L; Piotrowski, W; Thastrup, Ole.

In: British Journal of Pharmacology, Vol. 85, No. 3, 1985, p. 705-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ali, H, Christensen, SB, Foreman, JC, Pearce, FL, Piotrowski, W & Thastrup, O 1985, 'The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response', British Journal of Pharmacology, vol. 85, no. 3, pp. 705-12.

APA

Ali, H., Christensen, S. B., Foreman, J. C., Pearce, F. L., Piotrowski, W., & Thastrup, O. (1985). The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. British Journal of Pharmacology, 85(3), 705-12.

Vancouver

Ali H, Christensen SB, Foreman JC, Pearce FL, Piotrowski W, Thastrup O. The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. British Journal of Pharmacology. 1985;85(3):705-12.

Author

Ali, H ; Christensen, S B ; Foreman, J C ; Pearce, F L ; Piotrowski, W ; Thastrup, Ole. / The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. In: British Journal of Pharmacology. 1985 ; Vol. 85, No. 3. pp. 705-12.

Bibtex

@article{a606d8325ac443ae89be9791d3e8ee4a,
title = "The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response",
abstract = "The ability of thapsigargin and thapsigargicin to activate mast cells and leukocytes has been investigated. The thapsigargin-induced histamine release from rat peritoneal mast cells was found to be dependent on the concentration of thapsigargin, the purity of the mast cell preparations, and the number of mast cells in suspension. Thapsigargin induced histamine release from human basophil leukocytes. Thapsigargin induced beta-glucuronidase and lysozyme release from human neutrophil leukocytes. Thapsigargin caused a release of histamine from mesentery, lung, and heart mast cells of the rat, but only to a minor extent from the corresponding guinea-pig cells. Thapsigargicin induced histamine release from mesentery, lung, and heart mast cells of the rat at concentrations from 0.1 microM but provoked only a release from the corresponding guinea-pig cells in the concentration-range 0.16 to 1.6 microM. Thapsigargin increased the cytoplasmic free calcium level in intact human blood platelets at concentrations from 3.0 nM.",
keywords = "Adult, Animals, Blood Platelets, Calcium, Glucuronidase, Guinea Pigs, Histamine Release, Humans, Lactones, Leukocytes, Mast Cells, Muramidase, Plant Extracts, Plants, Medicinal, Potassium, Rats, Rats, Inbred Strains, Sesquiterpenes, Thapsigargin",
author = "H Ali and Christensen, {S B} and Foreman, {J C} and Pearce, {F L} and W Piotrowski and Ole Thastrup",
year = "1985",
language = "English",
volume = "85",
pages = "705--12",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

AU - Ali, H

AU - Christensen, S B

AU - Foreman, J C

AU - Pearce, F L

AU - Piotrowski, W

AU - Thastrup, Ole

PY - 1985

Y1 - 1985

N2 - The ability of thapsigargin and thapsigargicin to activate mast cells and leukocytes has been investigated. The thapsigargin-induced histamine release from rat peritoneal mast cells was found to be dependent on the concentration of thapsigargin, the purity of the mast cell preparations, and the number of mast cells in suspension. Thapsigargin induced histamine release from human basophil leukocytes. Thapsigargin induced beta-glucuronidase and lysozyme release from human neutrophil leukocytes. Thapsigargin caused a release of histamine from mesentery, lung, and heart mast cells of the rat, but only to a minor extent from the corresponding guinea-pig cells. Thapsigargicin induced histamine release from mesentery, lung, and heart mast cells of the rat at concentrations from 0.1 microM but provoked only a release from the corresponding guinea-pig cells in the concentration-range 0.16 to 1.6 microM. Thapsigargin increased the cytoplasmic free calcium level in intact human blood platelets at concentrations from 3.0 nM.

AB - The ability of thapsigargin and thapsigargicin to activate mast cells and leukocytes has been investigated. The thapsigargin-induced histamine release from rat peritoneal mast cells was found to be dependent on the concentration of thapsigargin, the purity of the mast cell preparations, and the number of mast cells in suspension. Thapsigargin induced histamine release from human basophil leukocytes. Thapsigargin induced beta-glucuronidase and lysozyme release from human neutrophil leukocytes. Thapsigargin caused a release of histamine from mesentery, lung, and heart mast cells of the rat, but only to a minor extent from the corresponding guinea-pig cells. Thapsigargicin induced histamine release from mesentery, lung, and heart mast cells of the rat at concentrations from 0.1 microM but provoked only a release from the corresponding guinea-pig cells in the concentration-range 0.16 to 1.6 microM. Thapsigargin increased the cytoplasmic free calcium level in intact human blood platelets at concentrations from 3.0 nM.

KW - Adult

KW - Animals

KW - Blood Platelets

KW - Calcium

KW - Glucuronidase

KW - Guinea Pigs

KW - Histamine Release

KW - Humans

KW - Lactones

KW - Leukocytes

KW - Mast Cells

KW - Muramidase

KW - Plant Extracts

KW - Plants, Medicinal

KW - Potassium

KW - Rats

KW - Rats, Inbred Strains

KW - Sesquiterpenes

KW - Thapsigargin

M3 - Journal article

C2 - 2411328

VL - 85

SP - 705

EP - 712

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 3

ER -

ID: 43350638