Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Tachykinins in the porcine pancreas : potent exocrine and endocrine effects via NK-1 receptors. / Schmidt, P T; Tornøe, K; Poulsen, Steen Seier; Rasmussen, T N; Holst, J J.

In: Pancreas, Vol. 20, No. 3, 04.2000, p. 241-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schmidt, PT, Tornøe, K, Poulsen, SS, Rasmussen, TN & Holst, JJ 2000, 'Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors', Pancreas, vol. 20, no. 3, pp. 241-7.

APA

Schmidt, P. T., Tornøe, K., Poulsen, S. S., Rasmussen, T. N., & Holst, J. J. (2000). Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors. Pancreas, 20(3), 241-7.

Vancouver

Schmidt PT, Tornøe K, Poulsen SS, Rasmussen TN, Holst JJ. Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors. Pancreas. 2000 Apr;20(3):241-7.

Author

Schmidt, P T ; Tornøe, K ; Poulsen, Steen Seier ; Rasmussen, T N ; Holst, J J. / Tachykinins in the porcine pancreas : potent exocrine and endocrine effects via NK-1 receptors. In: Pancreas. 2000 ; Vol. 20, No. 3. pp. 241-7.

Bibtex

@article{82a9c021d754449987d3fddbb63010df,
title = "Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors",
abstract = "The localization, release, and effects of substance P and neurokinin A were studied in the porcine pancreas and the localization of substance P immunoreactive nerve fibers was examined by immunohistochemistry. The effects of electrical vagus stimulation and capsaicin infusion on tachykinin release and the effects of substance P and neurokinin A infusion on insulin, glucagon, somatostatin, and exocrine secretion were studied using the isolated perfused porcine pancreas with intact vagal innervation. NK-1 and NK-2 receptor antagonists were used to investigate receptor involvement. Substance P immunoreactive nerve fibers were localized to islets of Langerhans, acini, ducts, and blood vessels. Vagus stimulation had no effect on substance P and neurokinin A release, whereas capsaicin infusion stimulated release of both. Substance P and neurokinin A infusion increased release of insulin, glucagon, and exocrine secretion, whereas somatostatin secretion was unaffected. The effect of substance P on insulin, glucagon, and exocrine secretion was blocked by the NK-1 receptor antagonist. The effect of electrical stimulation of vagus nerves on insulin and exocrine secretion was not influenced by tachykinin receptor antagonists. We conclude that tachykinins stimulate both endocrine and exocrine pancreatic functions through NK-1 receptors. Tachykinins are not involved in vagal regulation of pancreatic secretion in pigs but could constitute part of an alternative stimulatory system.",
keywords = "Animals, Capsaicin, Electric Stimulation, Glucagon, Immunohistochemistry, Insulin, Islets of Langerhans, Nerve Fibers, Neurokinin A, Pancreas, Receptors, Neurokinin-1, Somatostatin, Substance P, Swine, Tachykinins, Vagus Nerve",
author = "Schmidt, {P T} and K Torn{\o}e and Poulsen, {Steen Seier} and Rasmussen, {T N} and Holst, {J J}",
year = "2000",
month = apr,
language = "English",
volume = "20",
pages = "241--7",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Tachykinins in the porcine pancreas

T2 - potent exocrine and endocrine effects via NK-1 receptors

AU - Schmidt, P T

AU - Tornøe, K

AU - Poulsen, Steen Seier

AU - Rasmussen, T N

AU - Holst, J J

PY - 2000/4

Y1 - 2000/4

N2 - The localization, release, and effects of substance P and neurokinin A were studied in the porcine pancreas and the localization of substance P immunoreactive nerve fibers was examined by immunohistochemistry. The effects of electrical vagus stimulation and capsaicin infusion on tachykinin release and the effects of substance P and neurokinin A infusion on insulin, glucagon, somatostatin, and exocrine secretion were studied using the isolated perfused porcine pancreas with intact vagal innervation. NK-1 and NK-2 receptor antagonists were used to investigate receptor involvement. Substance P immunoreactive nerve fibers were localized to islets of Langerhans, acini, ducts, and blood vessels. Vagus stimulation had no effect on substance P and neurokinin A release, whereas capsaicin infusion stimulated release of both. Substance P and neurokinin A infusion increased release of insulin, glucagon, and exocrine secretion, whereas somatostatin secretion was unaffected. The effect of substance P on insulin, glucagon, and exocrine secretion was blocked by the NK-1 receptor antagonist. The effect of electrical stimulation of vagus nerves on insulin and exocrine secretion was not influenced by tachykinin receptor antagonists. We conclude that tachykinins stimulate both endocrine and exocrine pancreatic functions through NK-1 receptors. Tachykinins are not involved in vagal regulation of pancreatic secretion in pigs but could constitute part of an alternative stimulatory system.

AB - The localization, release, and effects of substance P and neurokinin A were studied in the porcine pancreas and the localization of substance P immunoreactive nerve fibers was examined by immunohistochemistry. The effects of electrical vagus stimulation and capsaicin infusion on tachykinin release and the effects of substance P and neurokinin A infusion on insulin, glucagon, somatostatin, and exocrine secretion were studied using the isolated perfused porcine pancreas with intact vagal innervation. NK-1 and NK-2 receptor antagonists were used to investigate receptor involvement. Substance P immunoreactive nerve fibers were localized to islets of Langerhans, acini, ducts, and blood vessels. Vagus stimulation had no effect on substance P and neurokinin A release, whereas capsaicin infusion stimulated release of both. Substance P and neurokinin A infusion increased release of insulin, glucagon, and exocrine secretion, whereas somatostatin secretion was unaffected. The effect of substance P on insulin, glucagon, and exocrine secretion was blocked by the NK-1 receptor antagonist. The effect of electrical stimulation of vagus nerves on insulin and exocrine secretion was not influenced by tachykinin receptor antagonists. We conclude that tachykinins stimulate both endocrine and exocrine pancreatic functions through NK-1 receptors. Tachykinins are not involved in vagal regulation of pancreatic secretion in pigs but could constitute part of an alternative stimulatory system.

KW - Animals

KW - Capsaicin

KW - Electric Stimulation

KW - Glucagon

KW - Immunohistochemistry

KW - Insulin

KW - Islets of Langerhans

KW - Nerve Fibers

KW - Neurokinin A

KW - Pancreas

KW - Receptors, Neurokinin-1

KW - Somatostatin

KW - Substance P

KW - Swine

KW - Tachykinins

KW - Vagus Nerve

M3 - Journal article

C2 - 10766449

VL - 20

SP - 241

EP - 247

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 3

ER -

ID: 47486461