Systemic adverse events and all-cause mortality following same-session bilateral intravitreal anti-VEGF injections: a systematic review
Research output: Contribution to journal › Review › Research › peer-review
Purpose: To review the risk of systemic adverse events and all-cause mortality following same-day bilateral anti-VEGF injections. Methods: Twelve literature databases were searched for studies on same-session bilateral intravitreal anti-VEGF injections. Studies reporting on systemic adverse events and mortality were included. Data extraction was made independently by two authors and discussed afterwards until consensus was reached. Results: Seven studies were included with a total of 13,406 intravitreal anti-VEGF injections (6703 bilateral injections sessions) given to 689 patients. Across all studies, mean age of patients ranged from 55.7 to 82.5 years, and mean follow-up times ranged from 1.3 to 41 months. Six studies reported on systemic adverse events: Two cases of non-fatal cardiac adverse events were reported after 12,964 injections (6482 bilateral injection sessions) in 626 patients. Four studies reported on death: 12 deaths were recorded after 6233 bilateral injection sessions in a total population of 554 subjects. Conclusions: We suggest that the risk of non-fatal systemic adverse events and death after same-session bilateral anti-VEGF injection is reasonably low, but larger studies with follow-ups of several years are needed to quantify the exact risk. Study registration.: Prospectively registered in PROSPERO, registration ID: CRD42023428254, registration date: 20/05/2023. [Figure not available: see fulltext.].
Original language | English |
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Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
Number of pages | 10 |
ISSN | 0721-832X |
DOIs | |
Publication status | Accepted/In press - 2024 |
Bibliographical note
Publisher Copyright:
© 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Adverse event, Anti-VEGF, Bilateral, Death, Injection, Intravitreal, Mortality, Risk, Same-day, Same-session, Systematic review
Research areas
ID: 379706560