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RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins. / Jairoce, Chenjerai; Macià, Dídac; Torres-Yaguana, Jorge P.; Mayer, Leonie; Vidal, Marta; Santano, Rebeca; Hurtado-Guerrero, Ramón; Reiter, Karine; Narum, David L.; Lopez-Gutierrez, Borja; Hamerly, Timothy; Sacarlal, Jahit; Aguilar, Ruth; Dinglasan, Rhoel R.; Moncunill, Gemma; Izquierdo, Luis; Dobaño, Carlota.
In:
Journal of Infectious Diseases, Vol. 229, No. 3, 2024, p. 795-799.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Jairoce, C, Macià, D, Torres-Yaguana, JP, Mayer, L, Vidal, M, Santano, R, Hurtado-Guerrero, R, Reiter, K, Narum, DL, Lopez-Gutierrez, B, Hamerly, T, Sacarlal, J, Aguilar, R, Dinglasan, RR, Moncunill, G, Izquierdo, L & Dobaño, C 2024, '
RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins',
Journal of Infectious Diseases, vol. 229, no. 3, pp. 795-799.
https://doi.org/10.1093/infdis/jiad471APA
Jairoce, C., Macià, D., Torres-Yaguana, J. P., Mayer, L., Vidal, M., Santano, R., Hurtado-Guerrero, R., Reiter, K., Narum, D. L., Lopez-Gutierrez, B., Hamerly, T., Sacarlal, J., Aguilar, R., Dinglasan, R. R., Moncunill, G., Izquierdo, L., & Dobaño, C. (2024).
RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins.
Journal of Infectious Diseases,
229(3), 795-799.
https://doi.org/10.1093/infdis/jiad471Vancouver
Jairoce C, Macià D, Torres-Yaguana JP, Mayer L, Vidal M, Santano R et al.
RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins.
Journal of Infectious Diseases. 2024;229(3):795-799.
https://doi.org/10.1093/infdis/jiad471Author
Jairoce, Chenjerai ; Macià, Dídac ; Torres-Yaguana, Jorge P. ; Mayer, Leonie ; Vidal, Marta ; Santano, Rebeca ; Hurtado-Guerrero, Ramón ; Reiter, Karine ; Narum, David L. ; Lopez-Gutierrez, Borja ; Hamerly, Timothy ; Sacarlal, Jahit ; Aguilar, Ruth ; Dinglasan, Rhoel R. ; Moncunill, Gemma ; Izquierdo, Luis ; Dobaño, Carlota. / RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins. In: Journal of Infectious Diseases. 2024 ; Vol. 229, No. 3. pp. 795-799.
Bibtex
@article{cce1360968f84ff1941c8c9acf5bed6f,
title = "RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins",
abstract = "The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.",
keywords = "antibodies, circumsporozoite protein (PfCSP), fucosylation, immunogenicity, malaria, Plasmodium falciparum, RTS,S",
author = "Chenjerai Jairoce and D{\'i}dac Maci{\`a} and Torres-Yaguana, {Jorge P.} and Leonie Mayer and Marta Vidal and Rebeca Santano and Ram{\'o}n Hurtado-Guerrero and Karine Reiter and Narum, {David L.} and Borja Lopez-Gutierrez and Timothy Hamerly and Jahit Sacarlal and Ruth Aguilar and Dinglasan, {Rhoel R.} and Gemma Moncunill and Luis Izquierdo and Carlota Doba{\~n}o",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2024",
doi = "10.1093/infdis/jiad471",
language = "English",
volume = "229",
pages = "795--799",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}
RIS
TY - JOUR
T1 - RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins
AU - Jairoce, Chenjerai
AU - Macià, Dídac
AU - Torres-Yaguana, Jorge P.
AU - Mayer, Leonie
AU - Vidal, Marta
AU - Santano, Rebeca
AU - Hurtado-Guerrero, Ramón
AU - Reiter, Karine
AU - Narum, David L.
AU - Lopez-Gutierrez, Borja
AU - Hamerly, Timothy
AU - Sacarlal, Jahit
AU - Aguilar, Ruth
AU - Dinglasan, Rhoel R.
AU - Moncunill, Gemma
AU - Izquierdo, Luis
AU - Dobaño, Carlota
N1 - Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2024
Y1 - 2024
N2 - The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.
AB - The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.
KW - antibodies
KW - circumsporozoite protein (PfCSP)
KW - fucosylation
KW - immunogenicity
KW - malaria
KW - Plasmodium falciparum
KW - RTS,S
U2 - 10.1093/infdis/jiad471
DO - 10.1093/infdis/jiad471
M3 - Journal article
C2 - 37889513
AN - SCOPUS:85187937655
VL - 229
SP - 795
EP - 799
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -
