Ratio of early transmitral inflow velocity to early diastolic strain rate predicts atrial fibrillation following acute myocardial infarction
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Ratio of early transmitral inflow velocity to early diastolic strain rate predicts atrial fibrillation following acute myocardial infarction. / Bjerregaard, Caroline Løkke; Olsen, Flemming Javier; Lassen, Mats Christian Højbjerg; Svartstein, Anne Sophie Winther; Hansen, Thomas Fritz; Galatius, Søren; Iversen, Allan; Pedersen, Sune; Biering-Sørensen, Tor.
In: International Journal of Cardiovascular Imaging, Vol. 40, No. 2, 2024, p. 331-340.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ratio of early transmitral inflow velocity to early diastolic strain rate predicts atrial fibrillation following acute myocardial infarction
AU - Bjerregaard, Caroline Løkke
AU - Olsen, Flemming Javier
AU - Lassen, Mats Christian Højbjerg
AU - Svartstein, Anne Sophie Winther
AU - Hansen, Thomas Fritz
AU - Galatius, Søren
AU - Iversen, Allan
AU - Pedersen, Sune
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2024
Y1 - 2024
N2 - The ratio of early transmitral filling velocity to early diastolic strain rate (E/SRe) has been proposed as a new non-invasive measurement of left ventricular filling pressure. We aimed to investigate the ability of E/SRe to predict atrial fibrillation (AF) after ST-elevation myocardial infarction (STEMI). This was a prospective cohort study of patients (n = 369) with STEMI. Patients underwent an echocardiographic examination a median of two days after pPCI. By echocardiography, transmitral early filling velocity (E) was measured by pulsed-wave Doppler, and early diastolic strain rate (SRe) was measured by speckle tracking of the left ventricle. E was indexed to SRe and the early myocardial relaxation velocity (e’) to obtain the E/SRe and E/e’, respectively. The endpoint was new-onset AF. During follow-up (median 5.6 years, IQR: 5.0–6.1 years), 23 (6%) of the 369 patients developed AF. In unadjusted analyses, both E/SRe and E/e’ were significantly associated with AF [E/SRe: HR = 1.06; (1.03–1.10); p < 0.001, per 10 increase] and [E/e’: HR = 1.11 (1.05–1.17); p < 0.001, per 1 increase] and had equal Harrell’s C-statistic of 0.71. However, only E/SRe remained an independent predictor after multivariable adjustments for clinical and echocardiographic parameters [E/SRe: HR = 1.06 (1.00–1.11); p = 0.044, per 10 increase]. E/SRe was further significantly associated with AF in patients with E/e’ < 14 HR = 1.09 (1.01–1.17); p = 0.030, per 10 increase), also after multivariable adjustments. E/SRe is an independent predictor of AF in STEMI patients, even in subjects with seemingly normal filling pressure.
AB - The ratio of early transmitral filling velocity to early diastolic strain rate (E/SRe) has been proposed as a new non-invasive measurement of left ventricular filling pressure. We aimed to investigate the ability of E/SRe to predict atrial fibrillation (AF) after ST-elevation myocardial infarction (STEMI). This was a prospective cohort study of patients (n = 369) with STEMI. Patients underwent an echocardiographic examination a median of two days after pPCI. By echocardiography, transmitral early filling velocity (E) was measured by pulsed-wave Doppler, and early diastolic strain rate (SRe) was measured by speckle tracking of the left ventricle. E was indexed to SRe and the early myocardial relaxation velocity (e’) to obtain the E/SRe and E/e’, respectively. The endpoint was new-onset AF. During follow-up (median 5.6 years, IQR: 5.0–6.1 years), 23 (6%) of the 369 patients developed AF. In unadjusted analyses, both E/SRe and E/e’ were significantly associated with AF [E/SRe: HR = 1.06; (1.03–1.10); p < 0.001, per 10 increase] and [E/e’: HR = 1.11 (1.05–1.17); p < 0.001, per 1 increase] and had equal Harrell’s C-statistic of 0.71. However, only E/SRe remained an independent predictor after multivariable adjustments for clinical and echocardiographic parameters [E/SRe: HR = 1.06 (1.00–1.11); p = 0.044, per 10 increase]. E/SRe was further significantly associated with AF in patients with E/e’ < 14 HR = 1.09 (1.01–1.17); p = 0.030, per 10 increase), also after multivariable adjustments. E/SRe is an independent predictor of AF in STEMI patients, even in subjects with seemingly normal filling pressure.
KW - Atrial fibrillation
KW - Diastolic function
KW - STEMI
KW - Strain imaging
U2 - 10.1007/s10554-023-02991-y
DO - 10.1007/s10554-023-02991-y
M3 - Journal article
C2 - 37957448
AN - SCOPUS:85176590195
VL - 40
SP - 331
EP - 340
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 2
ER -
ID: 374311630