Quantitation of glial fibrillary acidic protein in human brain tumours
Research output: Contribution to journal › Journal article › Research › peer-review
The glial fibrillary acidic protein (GFA) content of 58 human brain tumours was determined by quantitative immunoelectrophoresis, using monospecific antibody against GFA. Astrocytomas, glioblastomas, oligodendrogliomas, spongioblastomas, ependymomas and medulloblastomas contained relatively high amounts of GFA, up to 85 times the concentration in parietal grey substance of normal human brain. GFA was not found in neurinomas, meningiomas, adenomas of the hypophysis, or in a single case of metastasis of adenocarcinoma. Non-glial tumours of craniopharyngioma and haemangioblastoma were infiltrated by reactive astroglia and showed considerable amounts of GFA.
Original language | English |
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Journal | British Journal of Cancer |
Volume | 41 |
Issue number | 1 |
Pages (from-to) | 113-6 |
Number of pages | 3 |
ISSN | 0007-0920 |
Publication status | Published - 1980 |
Bibliographical note
Keywords: Albumins; Brain Neoplasms; Glioma; Humans; Immunoelectrophoresis; Neoplasm Proteins
ID: 21607599