Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis

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Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis. / Hansen, Eline Palm; Kringel, Helene; Thamsborg, Stig Milan; Jex, Aaron R.; Nejsum, Peter.

In: Veterinary Parasitology, Vol. 223, 15.06.2016, p. 30-33.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hansen, EP, Kringel, H, Thamsborg, SM, Jex, AR & Nejsum, P 2016, 'Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis', Veterinary Parasitology, vol. 223, pp. 30-33. https://doi.org/10.1016/j.vetpar.2016.03.025

APA

Hansen, E. P., Kringel, H., Thamsborg, S. M., Jex, A. R., & Nejsum, P. (2016). Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis. Veterinary Parasitology, 223, 30-33. https://doi.org/10.1016/j.vetpar.2016.03.025

Vancouver

Hansen EP, Kringel H, Thamsborg SM, Jex AR, Nejsum P. Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis. Veterinary Parasitology. 2016 Jun 15;223:30-33. https://doi.org/10.1016/j.vetpar.2016.03.025

Author

Hansen, Eline Palm ; Kringel, Helene ; Thamsborg, Stig Milan ; Jex, Aaron R. ; Nejsum, Peter. / Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis. In: Veterinary Parasitology. 2016 ; Vol. 223. pp. 30-33.

Bibtex

@article{55818d9b82134436abdaf8c99b0f40ba,
title = "Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis",
abstract = "microRNAs (miRNAs) are recently discovered as key regulators of gene translation and are becoming increasingly recognized for their involvement in various diseases. This study investigates the miRNA profile in pig serum during the course of an infection with the gastrointestinal parasite, Trichuris suis. Of this panel, the expression of selected miRNAs in serum from T. suis infected and uninfected pigs were determined by quantitative real time PCR using Exiqon Human Panel assays at 0, 2, 4, 6, 8 and 10 weeks post first infection (wpi). One miRNA, ssc-let-7d-3p, was significantly up-regulated in infected pigs 8 wpi. Interestingly, ssc-let-7d-3p shows high complementary to tsu-let-7a, which is the most highly transcribed miRNA in T. suis. The let-7 family miRNAs have been shown to post-transcriptionally regulate the translation of the helminth-controlling cytokine, IL-13, in a murine model for asthma and we hypothesize possible interactions between these host- and parasite-derived miRNAs and their immunomodulating roles.",
keywords = "Faculty of Health and Medical Sciences, Trichuris suis, Whipworm, Pig, miRNA, Biomarke",
author = "Hansen, {Eline Palm} and Helene Kringel and Thamsborg, {Stig Milan} and Jex, {Aaron R.} and Peter Nejsum",
year = "2016",
month = "6",
day = "15",
doi = "10.1016/j.vetpar.2016.03.025",
language = "English",
volume = "223",
pages = "30--33",
journal = "Veterinary Parasitology",
issn = "0304-4017",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Profiling circulating miRNAs in serum from pigs infected with the porcine whipworm, Trichuris suis

AU - Hansen, Eline Palm

AU - Kringel, Helene

AU - Thamsborg, Stig Milan

AU - Jex, Aaron R.

AU - Nejsum, Peter

PY - 2016/6/15

Y1 - 2016/6/15

N2 - microRNAs (miRNAs) are recently discovered as key regulators of gene translation and are becoming increasingly recognized for their involvement in various diseases. This study investigates the miRNA profile in pig serum during the course of an infection with the gastrointestinal parasite, Trichuris suis. Of this panel, the expression of selected miRNAs in serum from T. suis infected and uninfected pigs were determined by quantitative real time PCR using Exiqon Human Panel assays at 0, 2, 4, 6, 8 and 10 weeks post first infection (wpi). One miRNA, ssc-let-7d-3p, was significantly up-regulated in infected pigs 8 wpi. Interestingly, ssc-let-7d-3p shows high complementary to tsu-let-7a, which is the most highly transcribed miRNA in T. suis. The let-7 family miRNAs have been shown to post-transcriptionally regulate the translation of the helminth-controlling cytokine, IL-13, in a murine model for asthma and we hypothesize possible interactions between these host- and parasite-derived miRNAs and their immunomodulating roles.

AB - microRNAs (miRNAs) are recently discovered as key regulators of gene translation and are becoming increasingly recognized for their involvement in various diseases. This study investigates the miRNA profile in pig serum during the course of an infection with the gastrointestinal parasite, Trichuris suis. Of this panel, the expression of selected miRNAs in serum from T. suis infected and uninfected pigs were determined by quantitative real time PCR using Exiqon Human Panel assays at 0, 2, 4, 6, 8 and 10 weeks post first infection (wpi). One miRNA, ssc-let-7d-3p, was significantly up-regulated in infected pigs 8 wpi. Interestingly, ssc-let-7d-3p shows high complementary to tsu-let-7a, which is the most highly transcribed miRNA in T. suis. The let-7 family miRNAs have been shown to post-transcriptionally regulate the translation of the helminth-controlling cytokine, IL-13, in a murine model for asthma and we hypothesize possible interactions between these host- and parasite-derived miRNAs and their immunomodulating roles.

KW - Faculty of Health and Medical Sciences

KW - Trichuris suis

KW - Whipworm

KW - Pig

KW - miRNA

KW - Biomarke

UR - https://www.sciencedirect.com/science/article/pii/S0304401717304727?via%3Dihub

U2 - 10.1016/j.vetpar.2016.03.025

DO - 10.1016/j.vetpar.2016.03.025

M3 - Journal article

C2 - 27198773

VL - 223

SP - 30

EP - 33

JO - Veterinary Parasitology

JF - Veterinary Parasitology

SN - 0304-4017

ER -

ID: 161188640