PRECISION OF HISTOLOGICAL GRADING OF MALIGNANCY: Sources of variation in a histological scoring system for grading cancer of the larynx
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PRECISION OF HISTOLOGICAL GRADING OF MALIGNANCY : Sources of variation in a histological scoring system for grading cancer of the larynx. / Græm, Niels; Helweg‐Larsen, Karin; Keiding, Niels.
In: Acta Pathologica Microbiologica Scandinavica Section A Pathology, Vol. 88 A, No. 1-6, 07.1980, p. 307-317.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - PRECISION OF HISTOLOGICAL GRADING OF MALIGNANCY
T2 - Sources of variation in a histological scoring system for grading cancer of the larynx
AU - Græm, Niels
AU - Helweg‐Larsen, Karin
AU - Keiding, Niels
PY - 1980/7
Y1 - 1980/7
N2 - The precision of a grading system based upon average score of 8 items for histological evaluation of malignancy of epidermoid carcinomas of the larynx was studied by letting 6 pathologists examine biopsies from 22 new cases. Exploratory statistical tools as well as a statistical framework (variance component models) for separating and evaluating the noise components are suggested. The order of magnitude of the resulting overall measurement uncertainty allowed discrimination between patients, though if a patient is graded by only one pathologist, only results at the extremes of the scale of malignancy should be trusted as possible therapeutical guidance. Based upon an analysis of the basic structure of the grading system the single noise components making up the measurement uncertainty were determined. Of greatest importance was noise created by disagreement between the pathologists in their ranking of the patients on the scale of malignancy. Furthermore the pathologists used the individual items differently, and certain items seemed to conform little to the scoring system. An attempt to minimize these two last components was performed; however neither calibration of the pathologists nor omission of the deviating items improved the precision significantly.
AB - The precision of a grading system based upon average score of 8 items for histological evaluation of malignancy of epidermoid carcinomas of the larynx was studied by letting 6 pathologists examine biopsies from 22 new cases. Exploratory statistical tools as well as a statistical framework (variance component models) for separating and evaluating the noise components are suggested. The order of magnitude of the resulting overall measurement uncertainty allowed discrimination between patients, though if a patient is graded by only one pathologist, only results at the extremes of the scale of malignancy should be trusted as possible therapeutical guidance. Based upon an analysis of the basic structure of the grading system the single noise components making up the measurement uncertainty were determined. Of greatest importance was noise created by disagreement between the pathologists in their ranking of the patients on the scale of malignancy. Furthermore the pathologists used the individual items differently, and certain items seemed to conform little to the scoring system. An attempt to minimize these two last components was performed; however neither calibration of the pathologists nor omission of the deviating items improved the precision significantly.
KW - Cancer of the larynx
KW - histological grading
KW - however neither calibration of the pathologists nor omission of the deviating items improved the precision significantly
KW - variance component models
UR - http://www.scopus.com/inward/record.url?scp=0018891755&partnerID=8YFLogxK
U2 - 10.1111/j.1699-0463.1980.tb02501.x
DO - 10.1111/j.1699-0463.1980.tb02501.x
M3 - Journal article
C2 - 7468219
AN - SCOPUS:0018891755
VL - 88 A
SP - 307
EP - 317
JO - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
JF - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
SN - 0365-4184
IS - 1-6
ER -
ID: 202385928