Post transfusion purpura and anti-Zwb (-P1A2)
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Post transfusion purpura and anti-Zwb (-P1A2). / Taaning, E; Morling, N; Ovesen, H; Svejgaard, A.
In: HLA, Vol. 26, No. 2, 1985, p. 143-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Post transfusion purpura and anti-Zwb (-P1A2)
AU - Taaning, E
AU - Morling, N
AU - Ovesen, H
AU - Svejgaard, A
N1 - Keywords: Aged; Antibody Specificity; Blood Platelets; Blood Transfusion; Female; Humans; Isoantigens; Male; Middle Aged; Purpura, Thrombocytopenic
PY - 1985
Y1 - 1985
N2 - The first two cases of post transfusion purpura (PTP) due to recognized antibodies against the platelet specific antigen Zwb (P1A1) are described. In both cases, the antibodies were detectable in the platelet enzyme immuno-assay (ELISA), while the platelet specific alloantibodies could be ascertained neither in the platelet suspension immunofluorescence test (PSIFT) nor in the platelet fixation test (CFT) due to coexisting potent multispecific HLA-antibodies. The two sera reacted in parallel (coefficient of correlation, r = 0.87; P less than 10(-5) and the reactions of the two sera were negatively associated with the Zwa-antigen (P = 0.0002 and 0.003, respectively). Thus, PTP may be caused not only by anti-Zwa (-P1A1) but also by anti-Zwb.
AB - The first two cases of post transfusion purpura (PTP) due to recognized antibodies against the platelet specific antigen Zwb (P1A1) are described. In both cases, the antibodies were detectable in the platelet enzyme immuno-assay (ELISA), while the platelet specific alloantibodies could be ascertained neither in the platelet suspension immunofluorescence test (PSIFT) nor in the platelet fixation test (CFT) due to coexisting potent multispecific HLA-antibodies. The two sera reacted in parallel (coefficient of correlation, r = 0.87; P less than 10(-5) and the reactions of the two sera were negatively associated with the Zwa-antigen (P = 0.0002 and 0.003, respectively). Thus, PTP may be caused not only by anti-Zwa (-P1A1) but also by anti-Zwb.
M3 - Journal article
C2 - 4060138
VL - 26
SP - 143
EP - 146
JO - HLA
JF - HLA
SN - 2059-2302
IS - 2
ER -
ID: 21610744