p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

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p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. / Christoffersen, N R; Shalgi, R; Frankel, L B; Leucci, E; Lees, M; Klausen, M; Pilpel, Y; Nielsen, F C; Oren, M; Lund, Anders H.

In: Cell Death and Differentiation, Vol. 17, No. 2, 02.2010, p. 236-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christoffersen, NR, Shalgi, R, Frankel, LB, Leucci, E, Lees, M, Klausen, M, Pilpel, Y, Nielsen, FC, Oren, M & Lund, AH 2010, 'p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC', Cell Death and Differentiation, vol. 17, no. 2, pp. 236-45. https://doi.org/10.1038/cdd.2009.109

APA

Christoffersen, N. R., Shalgi, R., Frankel, L. B., Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F. C., Oren, M., & Lund, A. H. (2010). p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death and Differentiation, 17(2), 236-45. https://doi.org/10.1038/cdd.2009.109

Vancouver

Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M et al. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death and Differentiation. 2010 Feb;17(2):236-45. https://doi.org/10.1038/cdd.2009.109

Author

Christoffersen, N R ; Shalgi, R ; Frankel, L B ; Leucci, E ; Lees, M ; Klausen, M ; Pilpel, Y ; Nielsen, F C ; Oren, M ; Lund, Anders H. / p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. In: Cell Death and Differentiation. 2010 ; Vol. 17, No. 2. pp. 236-45.

Bibtex

@article{ede2d21deb5e41ea83646abfa982967e,
title = "p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC",
abstract = "Aberrant oncogene activation induces cellular senescence, an irreversible growth arrest that acts as a barrier against tumorigenesis. To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF. Among the regulated miRNAs, both miR-34a and miR-146a were strongly induced during senescence. Although members of the miR-34 family are known to be transcriptionally regulated by p53, we find that miR-34a is regulated independently of p53 during oncogene-induced senescence. Instead, upregulation of miR-34a is mediated by the ETS family transcription factor, ELK1. During senescence, miR-34a targets the important proto-oncogene MYC and our data suggest that miR-34a thereby coordinately controls a set of cell cycle regulators. Hence, in addition to its integration in the p53 pathway, we show that alternative cancer-related pathways regulate miR-34a, emphasising its significance as a tumour suppressor.",
keywords = "Cell Aging, Cell Cycle, Cell Division, Cell Line, Transformed, Fibroblasts, Humans, MicroRNAs, Neoplasms, Oncogenes, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-myc, Tumor Suppressor Protein p53, Up-Regulation, ets-Domain Protein Elk-1",
author = "Christoffersen, {N R} and R Shalgi and Frankel, {L B} and E Leucci and M Lees and M Klausen and Y Pilpel and Nielsen, {F C} and M Oren and Lund, {Anders H.}",
year = "2010",
month = feb,
doi = "10.1038/cdd.2009.109",
language = "English",
volume = "17",
pages = "236--45",
journal = "Cell Differentiation and Development",
issn = "1350-9047",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

AU - Christoffersen, N R

AU - Shalgi, R

AU - Frankel, L B

AU - Leucci, E

AU - Lees, M

AU - Klausen, M

AU - Pilpel, Y

AU - Nielsen, F C

AU - Oren, M

AU - Lund, Anders H.

PY - 2010/2

Y1 - 2010/2

N2 - Aberrant oncogene activation induces cellular senescence, an irreversible growth arrest that acts as a barrier against tumorigenesis. To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF. Among the regulated miRNAs, both miR-34a and miR-146a were strongly induced during senescence. Although members of the miR-34 family are known to be transcriptionally regulated by p53, we find that miR-34a is regulated independently of p53 during oncogene-induced senescence. Instead, upregulation of miR-34a is mediated by the ETS family transcription factor, ELK1. During senescence, miR-34a targets the important proto-oncogene MYC and our data suggest that miR-34a thereby coordinately controls a set of cell cycle regulators. Hence, in addition to its integration in the p53 pathway, we show that alternative cancer-related pathways regulate miR-34a, emphasising its significance as a tumour suppressor.

AB - Aberrant oncogene activation induces cellular senescence, an irreversible growth arrest that acts as a barrier against tumorigenesis. To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF. Among the regulated miRNAs, both miR-34a and miR-146a were strongly induced during senescence. Although members of the miR-34 family are known to be transcriptionally regulated by p53, we find that miR-34a is regulated independently of p53 during oncogene-induced senescence. Instead, upregulation of miR-34a is mediated by the ETS family transcription factor, ELK1. During senescence, miR-34a targets the important proto-oncogene MYC and our data suggest that miR-34a thereby coordinately controls a set of cell cycle regulators. Hence, in addition to its integration in the p53 pathway, we show that alternative cancer-related pathways regulate miR-34a, emphasising its significance as a tumour suppressor.

KW - Cell Aging

KW - Cell Cycle

KW - Cell Division

KW - Cell Line, Transformed

KW - Fibroblasts

KW - Humans

KW - MicroRNAs

KW - Neoplasms

KW - Oncogenes

KW - Proto-Oncogene Proteins B-raf

KW - Proto-Oncogene Proteins c-myc

KW - Tumor Suppressor Protein p53

KW - Up-Regulation

KW - ets-Domain Protein Elk-1

U2 - 10.1038/cdd.2009.109

DO - 10.1038/cdd.2009.109

M3 - Journal article

C2 - 19696787

VL - 17

SP - 236

EP - 245

JO - Cell Differentiation and Development

JF - Cell Differentiation and Development

SN - 1350-9047

IS - 2

ER -

ID: 50503724