Over-estimation of glomerular filtration rate by single injection [51Cr]EDTA plasma clearance determination in patients with ascites
Research output: Contribution to journal › Journal article › Research › peer-review
The total plasma (Clt) and the renal plasma (Clr) clearances of [51Cr]EDTA were determined simultaneously in nine patients with ascites due to liver cirrhosis. Clt (mean 78 ml/min, range 34-115 ml/min) was significantly higher than Clr (mean 52 ml/min, range 13-96 ml/min, P < 0.005). The ascitic fluid-plasma activity ratio of [51Cr]EDTA increased throughout the investigation period (5h). The results suggest that [51Cr]EDTA equilibrates slowly with the peritoneal space which indicates that Clt will over-estimate the glomerular filtration rate by approximately 20 ml/min in patients with ascites. To assess glomerular filtration rate in presence of ascites, the renal plasma clearance of [51Cr]EDTA should be used instead of the total plasma clearance.
Original language | English |
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Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
Volume | 40 |
Issue number | 3 |
Pages (from-to) | 279-84 |
Number of pages | 5 |
ISSN | 0036-5513 |
Publication status | Published - 1980 |
Bibliographical note
Keywords: Adult; Age Factors; Ascites; Body Weight; Chromium Radioisotopes; Creatinine; Edetic Acid; Female; Glomerular Filtration Rate; Humans; Kidney; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors
ID: 19398521