Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. / Vringer, Esmee; Heilig, Rosalie; Riley, Joel S; Black, Annabel; Cloix, Catherine; Skalka, George; Montes-Gómez, Alfredo E; Aguado, Aurore; Lilla, Sergio; Walczak, Henning; Gyrd-Hansen, Mads; Murphy, Daniel J; Huang, Danny T; Zanivan, Sara; Tait, Stephen Wg.

In: The EMBO Journal, 09.02.2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vringer, E, Heilig, R, Riley, JS, Black, A, Cloix, C, Skalka, G, Montes-Gómez, AE, Aguado, A, Lilla, S, Walczak, H, Gyrd-Hansen, M, Murphy, DJ, Huang, DT, Zanivan, S & Tait, SW 2024, 'Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response', The EMBO Journal. https://doi.org/10.1038/s44318-024-00044-1

APA

Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., & Tait, S. W. (2024). Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. The EMBO Journal. https://doi.org/10.1038/s44318-024-00044-1

Vancouver

Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G et al. Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. The EMBO Journal. 2024 Feb 9. https://doi.org/10.1038/s44318-024-00044-1

Author

Vringer, Esmee ; Heilig, Rosalie ; Riley, Joel S ; Black, Annabel ; Cloix, Catherine ; Skalka, George ; Montes-Gómez, Alfredo E ; Aguado, Aurore ; Lilla, Sergio ; Walczak, Henning ; Gyrd-Hansen, Mads ; Murphy, Daniel J ; Huang, Danny T ; Zanivan, Sara ; Tait, Stephen Wg. / Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. In: The EMBO Journal. 2024.

Bibtex

@article{95227e2e2cdd499fb7533861c5015f72,

title = "Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response",

abstract = "Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability to elicit anti-tumour immunity. Nonetheless, how MOMP triggers inflammation and how the cell regulates this remains poorly defined. We find that upon MOMP, many proteins localised either to inner or outer mitochondrial membranes are ubiquitylated in a promiscuous manner. This extensive ubiquitylation serves to recruit the essential adaptor molecule NEMO, leading to the activation of pro-inflammatory NF-κB signalling. We show that disruption of mitochondrial outer membrane integrity through different means leads to the engagement of a similar pro-inflammatory signalling platform. Therefore, mitochondrial integrity directly controls inflammation, such that permeabilised mitochondria initiate NF-κB signalling.",

author = "Esmee Vringer and Rosalie Heilig and Riley, {Joel S} and Annabel Black and Catherine Cloix and George Skalka and Montes-G{\'o}mez, {Alfredo E} and Aurore Aguado and Sergio Lilla and Henning Walczak and Mads Gyrd-Hansen and Murphy, {Daniel J} and Huang, {Danny T} and Sara Zanivan and Tait, {Stephen Wg}",

note = "{\textcopyright} 2024. The Author(s).",

year = "2024",

month = feb,

day = "9",

doi = "10.1038/s44318-024-00044-1",

language = "English",

journal = "E M B O Journal",

issn = "0261-4189",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

AU - Vringer, Esmee

AU - Heilig, Rosalie

AU - Riley, Joel S

AU - Black, Annabel

AU - Cloix, Catherine

AU - Skalka, George

AU - Montes-Gómez, Alfredo E

AU - Aguado, Aurore

AU - Lilla, Sergio

AU - Walczak, Henning

AU - Gyrd-Hansen, Mads

AU - Murphy, Daniel J

AU - Huang, Danny T

AU - Zanivan, Sara

AU - Tait, Stephen Wg

PY - 2024/2/9

Y1 - 2024/2/9

N2 - Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability to elicit anti-tumour immunity. Nonetheless, how MOMP triggers inflammation and how the cell regulates this remains poorly defined. We find that upon MOMP, many proteins localised either to inner or outer mitochondrial membranes are ubiquitylated in a promiscuous manner. This extensive ubiquitylation serves to recruit the essential adaptor molecule NEMO, leading to the activation of pro-inflammatory NF-κB signalling. We show that disruption of mitochondrial outer membrane integrity through different means leads to the engagement of a similar pro-inflammatory signalling platform. Therefore, mitochondrial integrity directly controls inflammation, such that permeabilised mitochondria initiate NF-κB signalling.

AB - Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to be inherently pro-inflammatory with emerging cellular roles, including its ability to elicit anti-tumour immunity. Nonetheless, how MOMP triggers inflammation and how the cell regulates this remains poorly defined. We find that upon MOMP, many proteins localised either to inner or outer mitochondrial membranes are ubiquitylated in a promiscuous manner. This extensive ubiquitylation serves to recruit the essential adaptor molecule NEMO, leading to the activation of pro-inflammatory NF-κB signalling. We show that disruption of mitochondrial outer membrane integrity through different means leads to the engagement of a similar pro-inflammatory signalling platform. Therefore, mitochondrial integrity directly controls inflammation, such that permeabilised mitochondria initiate NF-κB signalling.

U2 - 10.1038/s44318-024-00044-1

DO - 10.1038/s44318-024-00044-1

M3 - Journal article

C2 - 38337057

JO - E M B O Journal

JF - E M B O Journal

SN - 0261-4189

ER -

ID: 382761260

Faculty of Law