Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein.

Research output: Contribution to journalJournal articleResearchpeer-review

  • Philip J Young
  • Klaus T Jensen
  • Lisa R Burger
  • David J Pintel
  • Christian L Lorson
The small nonstructural protein NS2 of the minute virus of mice (MVM) is required for efficient viral replication, although its mode of action is unclear. Here we demonstrate that NS2 and survival motor neuron protein (Smn) interact in vitro and in vivo. NS2 and Smn also colocalize in infected nuclei at late times following MVM infection.
Original languageEnglish
JournalJournal of Virology
Volume76
Issue number12
Pages (from-to)6364-9
Number of pages5
ISSN0022-538X
Publication statusPublished - 2002
Externally publishedYes

Bibliographical note

Keywords: Animals; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Humans; Mice; Minute virus of mice; Nerve Tissue Proteins; Parvoviridae Infections; RNA-Binding Proteins; Viral Nonstructural Proteins; Virus Replication

ID: 5034254