Identifies and discusses methodological pitfalls that may help explain why many questions around early detection (ED) and duration of untreated psychosis (DUP) are still unsolved. This paper concentrates on pitfalls in sampling, measurement, and data analyses. The main problems seem to be: (1) Sampling: Referral bias, exclusion of patients, patient refusal, and patients lost to follow-up; (2) Measurement: Reliability, which is particularly cogent for multisite investigations, and validity including start of illness, start of psychosis, diagnoses, start of treatment, the relationship between ED and DUP and choice of outcome measures; (3) Data analyses: Overlooking threshold effects of DUP, improper control for baseline scores, and lack of control for confounders. Several of these pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)