Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease
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Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease. / Damsgaard, Line; Janbek, Janet; Laursen, Thomas M; Høgh, Peter; Vestergaard, Karsten; Gottrup, Hanne; Jensen-Dahm, Christina; Waldemar, Gunhild.
In: Alzheimer's & Dementia, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease
AU - Damsgaard, Line
AU - Janbek, Janet
AU - Laursen, Thomas M
AU - Høgh, Peter
AU - Vestergaard, Karsten
AU - Gottrup, Hanne
AU - Jensen-Dahm, Christina
AU - Waldemar, Gunhild
N1 - © 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map morbidity prior to YOAD diagnosis.METHODS: In a register-based incidence density matched nested case-control study, we examined hospital-diagnosed morbidity for people diagnosed with YOAD in Danish memory clinics during 2016-2020 compared to controls in a 10-year period. Conditional logistic regression produced incidence rate ratios (IRRs).RESULTS: The study included 1745 cases and 5235 controls. YOAD patients had a higher morbidity burden in the year immediately before dementia diagnosis, for certain disorders up to 10 years before. This was especially evident for psychiatric morbidity with the highest increased IRRs throughout the entire period and IRR 1.43 (95% confidence interval 1.14-1.79) in the 5-10-years before dementia diagnosis.DISCUSSION: YOAD patients display a different pattern of morbidity up to 10 years prior to diagnosis. Awareness of specific alterations in morbidity may improve efforts toward a timely diagnosis.HIGHLIGHTS: Retrospective, nested case-control study of young onset Alzheimer's disease (YOAD). YOAD cases had a higher morbidity burden than controls. YOAD cases had a higher psychiatric morbidity burden up to 10 years before diagnosis. Altered morbidity patterns could serve as an early warning sign of YOAD.
AB - INTRODUCTION: Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map morbidity prior to YOAD diagnosis.METHODS: In a register-based incidence density matched nested case-control study, we examined hospital-diagnosed morbidity for people diagnosed with YOAD in Danish memory clinics during 2016-2020 compared to controls in a 10-year period. Conditional logistic regression produced incidence rate ratios (IRRs).RESULTS: The study included 1745 cases and 5235 controls. YOAD patients had a higher morbidity burden in the year immediately before dementia diagnosis, for certain disorders up to 10 years before. This was especially evident for psychiatric morbidity with the highest increased IRRs throughout the entire period and IRR 1.43 (95% confidence interval 1.14-1.79) in the 5-10-years before dementia diagnosis.DISCUSSION: YOAD patients display a different pattern of morbidity up to 10 years prior to diagnosis. Awareness of specific alterations in morbidity may improve efforts toward a timely diagnosis.HIGHLIGHTS: Retrospective, nested case-control study of young onset Alzheimer's disease (YOAD). YOAD cases had a higher morbidity burden than controls. YOAD cases had a higher psychiatric morbidity burden up to 10 years before diagnosis. Altered morbidity patterns could serve as an early warning sign of YOAD.
U2 - 10.1002/alz.13681
DO - 10.1002/alz.13681
M3 - Journal article
C2 - 38294143
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
SN - 1552-5260
ER -
ID: 381850240