Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function
Research output: Contribution to journal › Journal article › Research › peer-review
AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.
Original language | English |
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Journal | European Heart Journal |
Volume | 24 |
Issue number | 9 |
Pages (from-to) | 863-70 |
Number of pages | 7 |
ISSN | 0195-668X |
Publication status | Published - 2003 |
Bibliographical note
Keywords: Aged; Cohort Studies; Confidence Intervals; Female; Heart Failure; Hospital Mortality; Hospitalization; Humans; Male; Prognosis; Survival Analysis; Ventricular Dysfunction, Left
ID: 17397480