Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. / Sitnicka, Ewa; Bryder, David; Theilgaard-Mönch, Kim; Buza-Vidas, Natalija; Adolfsson, Jörgen; Jacobsen, Sten Eirik W.

In: Immunity, Vol. 17, No. 4, 2002, p. 463-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sitnicka, E, Bryder, D, Theilgaard-Mönch, K, Buza-Vidas, N, Adolfsson, J & Jacobsen, SEW 2002, 'Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.', Immunity, vol. 17, no. 4, pp. 463-72.

APA

Sitnicka, E., Bryder, D., Theilgaard-Mönch, K., Buza-Vidas, N., Adolfsson, J., & Jacobsen, S. E. W. (2002). Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity, 17(4), 463-72.

Vancouver

Sitnicka E, Bryder D, Theilgaard-Mönch K, Buza-Vidas N, Adolfsson J, Jacobsen SEW. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity. 2002;17(4):463-72.

Author

Sitnicka, Ewa ; Bryder, David ; Theilgaard-Mönch, Kim ; Buza-Vidas, Natalija ; Adolfsson, Jörgen ; Jacobsen, Sten Eirik W. / Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. In: Immunity. 2002 ; Vol. 17, No. 4. pp. 463-72.

Bibtex

@article{1714728058af11dd8d9f000ea68e967b,
title = "Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.",
abstract = "The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.",
author = "Ewa Sitnicka and David Bryder and Kim Theilgaard-M{\"o}nch and Natalija Buza-Vidas and J{\"o}rgen Adolfsson and Jacobsen, {Sten Eirik W}",
note = "Keywords: Animals; Hematopoietic Stem Cells; Ligands; Lymphopoiesis; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelopoiesis; Phenotype; Recombinant Proteins; Stem Cell Factor",
year = "2002",
language = "English",
volume = "17",
pages = "463--72",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

AU - Sitnicka, Ewa

AU - Bryder, David

AU - Theilgaard-Mönch, Kim

AU - Buza-Vidas, Natalija

AU - Adolfsson, Jörgen

AU - Jacobsen, Sten Eirik W

N1 - Keywords: Animals; Hematopoietic Stem Cells; Ligands; Lymphopoiesis; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelopoiesis; Phenotype; Recombinant Proteins; Stem Cell Factor

PY - 2002

Y1 - 2002

N2 - The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.

AB - The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.

M3 - Journal article

C2 - 12387740

VL - 17

SP - 463

EP - 472

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 4

ER -

ID: 5142947