Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. / Madsbad, S; Bjerregaard, B; Henriksen, Jens Henrik Sahl; Juhl, E; Kehlet, H.

In: Gut, Vol. 21, No. 1, 1980, p. 52-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsbad, S, Bjerregaard, B, Henriksen, JHS, Juhl, E & Kehlet, H 1980, 'Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis', Gut, vol. 21, no. 1, pp. 52-6.

APA

Madsbad, S., Bjerregaard, B., Henriksen, J. H. S., Juhl, E., & Kehlet, H. (1980). Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. Gut, 21(1), 52-6.

Vancouver

Madsbad S, Bjerregaard B, Henriksen JHS, Juhl E, Kehlet H. Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. Gut. 1980;21(1):52-6.

Author

Madsbad, S ; Bjerregaard, B ; Henriksen, Jens Henrik Sahl ; Juhl, E ; Kehlet, H. / Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. In: Gut. 1980 ; Vol. 21, No. 1. pp. 52-6.

Bibtex

@article{635c85b04e1211df928f000ea68e967b,
title = "Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis",
abstract = "Fourteen patients with liver cirrhosis received oral prednisone or prednisolone (0.3 mg per kg) randomised on two consecutive days. Serum prednisone and prednisolone were measured over the following four hours. Mean serum prednisolone concentration after oral prednisone decreased with impaired liver function estimated by galactose elimination capacity (r = 0.64, P less than 0.03). Mean serum prednisolone concentration after oral prednisone in the seven patients with severely impaired liver function was only 53% (P less than 0.05) of that observed in the seven patients with slightly impaired liver function. Conversely, mean serum prednisone concentration after oral prednisone in the patients with severely impaired liver function was 74% higher (P = 0.05) than in patients with slightly impaired liver function. Mean serum prednisolone after oral prednisolone was independent of liver function. As only prednisolone exerts glucocorticoid activity, our results indicate that prednisolone should be preferred to prednisone in the treatment of patients with impaired liver function.",
author = "S Madsbad and B Bjerregaard and Henriksen, {Jens Henrik Sahl} and E Juhl and H Kehlet",
note = "Keywords: Administration, Oral; Adult; Female; Humans; Kinetics; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prednisolone; Prednisone",
year = "1980",
language = "English",
volume = "21",
pages = "52--6",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "1",

}

RIS

TY - JOUR

T1 - Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis

AU - Madsbad, S

AU - Bjerregaard, B

AU - Henriksen, Jens Henrik Sahl

AU - Juhl, E

AU - Kehlet, H

N1 - Keywords: Administration, Oral; Adult; Female; Humans; Kinetics; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prednisolone; Prednisone

PY - 1980

Y1 - 1980

N2 - Fourteen patients with liver cirrhosis received oral prednisone or prednisolone (0.3 mg per kg) randomised on two consecutive days. Serum prednisone and prednisolone were measured over the following four hours. Mean serum prednisolone concentration after oral prednisone decreased with impaired liver function estimated by galactose elimination capacity (r = 0.64, P less than 0.03). Mean serum prednisolone concentration after oral prednisone in the seven patients with severely impaired liver function was only 53% (P less than 0.05) of that observed in the seven patients with slightly impaired liver function. Conversely, mean serum prednisone concentration after oral prednisone in the patients with severely impaired liver function was 74% higher (P = 0.05) than in patients with slightly impaired liver function. Mean serum prednisolone after oral prednisolone was independent of liver function. As only prednisolone exerts glucocorticoid activity, our results indicate that prednisolone should be preferred to prednisone in the treatment of patients with impaired liver function.

AB - Fourteen patients with liver cirrhosis received oral prednisone or prednisolone (0.3 mg per kg) randomised on two consecutive days. Serum prednisone and prednisolone were measured over the following four hours. Mean serum prednisolone concentration after oral prednisone decreased with impaired liver function estimated by galactose elimination capacity (r = 0.64, P less than 0.03). Mean serum prednisolone concentration after oral prednisone in the seven patients with severely impaired liver function was only 53% (P less than 0.05) of that observed in the seven patients with slightly impaired liver function. Conversely, mean serum prednisone concentration after oral prednisone in the patients with severely impaired liver function was 74% higher (P = 0.05) than in patients with slightly impaired liver function. Mean serum prednisolone after oral prednisolone was independent of liver function. As only prednisolone exerts glucocorticoid activity, our results indicate that prednisolone should be preferred to prednisone in the treatment of patients with impaired liver function.

M3 - Journal article

C2 - 7364321

VL - 21

SP - 52

EP - 56

JO - Gut

JF - Gut

SN - 0017-5749

IS - 1

ER -

ID: 19398588