Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study
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Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study. / AS Henning, Mattias; Hother, Christoffer E.; Banasik, Karina; Ibler, Kristina S.; Rye Ostrowski, Sisse; Erikstrup, Christian; Nielsen, Kaspar R.; Ullum, Henrik; Hjalgrim, Henrik; Hansen, Thomas F.; Kaspersen, Kathrine A.; Sørensen, Betina S.; Sækmose, Susanne G.; Jemec, Gregor B.E.; Pedersen, Ole B.
In: Scandinavian Journal of Immunology, Vol. 95, No. 5, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study
AU - AS Henning, Mattias
AU - Hother, Christoffer E.
AU - Banasik, Karina
AU - Ibler, Kristina S.
AU - Rye Ostrowski, Sisse
AU - Erikstrup, Christian
AU - Nielsen, Kaspar R.
AU - Ullum, Henrik
AU - Hjalgrim, Henrik
AU - Hansen, Thomas F.
AU - Kaspersen, Kathrine A.
AU - Sørensen, Betina S.
AU - Sækmose, Susanne G.
AU - Jemec, Gregor B.E.
AU - Pedersen, Ole B.
N1 - Publisher Copyright: © 2022 The Scandinavian Foundation for Immunology.
PY - 2022
Y1 - 2022
N2 - Familial clustering of the skin disease primary hyperhidrosis suggests a genetic component to the disease. The human leucocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No study has investigated whether the HLA genes are involved in the pathogenesis of hyperhidrosis. We, therefore, compared HLA alleles in individuals with and without hyperhidrosis in this study of 65 000 blood donors. In this retrospective cohort study, we retrieved information on individuals with and without hyperhidrosis using self-reported questionnaires, the Danish National Patient Registry and the Danish National Prescription Registry on participants recruited to the Danish Blood Donor Study between 2010 and 2019. Association tests using logistic regression were conducted for each HLA allele corrected for sex, age, body mass index, smoking and principal components. Overall, 145 of 65 795 (0.2%) participants had hospital diagnosed hyperhidrosis. Similarly, 1379 of 15 530 (8.9%) participants had moderate-severe self-reported hyperhidrosis, of whom 447 (2.9%) had severe self-reported hyperhidrosis. Altogether, 28 participants had both hospital diagnosed and moderate-severe self-reported hyperhidrosis. Severe self-reported hyperhidrosis was associated with HLA-A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32-136.70; n = 7; P <.001). Moderate-severe self-reported hyperhidrosis and hospital diagnosed hyperhidrosis were not associated with any HLA. The association between hyperhidrosis and HLA-A*80:01 was based on a very small number of cases and not replicated in other patient subsets, and therefore likely a chance finding. Thus, this study suggests that genes other than the HLA are involved in the pathogenesis of hyperhidrosis.
AB - Familial clustering of the skin disease primary hyperhidrosis suggests a genetic component to the disease. The human leucocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No study has investigated whether the HLA genes are involved in the pathogenesis of hyperhidrosis. We, therefore, compared HLA alleles in individuals with and without hyperhidrosis in this study of 65 000 blood donors. In this retrospective cohort study, we retrieved information on individuals with and without hyperhidrosis using self-reported questionnaires, the Danish National Patient Registry and the Danish National Prescription Registry on participants recruited to the Danish Blood Donor Study between 2010 and 2019. Association tests using logistic regression were conducted for each HLA allele corrected for sex, age, body mass index, smoking and principal components. Overall, 145 of 65 795 (0.2%) participants had hospital diagnosed hyperhidrosis. Similarly, 1379 of 15 530 (8.9%) participants had moderate-severe self-reported hyperhidrosis, of whom 447 (2.9%) had severe self-reported hyperhidrosis. Altogether, 28 participants had both hospital diagnosed and moderate-severe self-reported hyperhidrosis. Severe self-reported hyperhidrosis was associated with HLA-A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32-136.70; n = 7; P <.001). Moderate-severe self-reported hyperhidrosis and hospital diagnosed hyperhidrosis were not associated with any HLA. The association between hyperhidrosis and HLA-A*80:01 was based on a very small number of cases and not replicated in other patient subsets, and therefore likely a chance finding. Thus, this study suggests that genes other than the HLA are involved in the pathogenesis of hyperhidrosis.
KW - blood donors
KW - HLA antigens
KW - hyperhidrosis
U2 - 10.1111/sji.13150
DO - 10.1111/sji.13150
M3 - Journal article
C2 - 35212011
AN - SCOPUS:85125892819
VL - 95
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 5
ER -
ID: 300912956