How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- microorganisms-08-01164-v2
Final published version, 1.06 MB, PDF document
BACKGROUND: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases.
METHODS: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12.
RESULTS: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438-830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events.
CONCLUSION: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.
Original language | English |
---|---|
Article number | 1164 |
Journal | Microorganisms |
Volume | 8 |
Number of pages | 16 |
ISSN | 2076-2607 |
DOIs | |
Publication status | Published - 2020 |
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 255556977