Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability

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Standard

Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability. / Hertz, M M; Paulson, O B.

In: The Journal of Clinical Investigation, Vol. 65, No. 5, 05.1980, p. 1145-51.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hertz, MM & Paulson, OB 1980, 'Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability', The Journal of Clinical Investigation, vol. 65, no. 5, pp. 1145-51. https://doi.org/10.1172/JCI109769

APA

Hertz, M. M., & Paulson, O. B. (1980). Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability. The Journal of Clinical Investigation, 65(5), 1145-51. https://doi.org/10.1172/JCI109769

Vancouver

Hertz MM, Paulson OB. Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability. The Journal of Clinical Investigation. 1980 May;65(5):1145-51. https://doi.org/10.1172/JCI109769

Author

Hertz, M M ; Paulson, O B. / Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability. In: The Journal of Clinical Investigation. 1980 ; Vol. 65, No. 5. pp. 1145-51.

Bibtex

@article{d4309b0e2bde4a1bb7ce9ac9d5d03a15,
title = "Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability",
abstract = "Blood-brain barrier permeability studies made in man using the indicator dilution method revealed that the extraction of the test substance increases during the upslope of the venous (outflow) dilution curve. The present study aimed to obviate the possibility that this could result from intravascular phenomena, such as interlaminar diffusion (the result of differences in molecular size) and erythrocyte carriage. Several reference substances were employed for the determination of the extraction in order that careful correction could be made for differences in intravascular behavior of the test and reference substance. The test substances studied were D-glucose, L-phenylalanine, water, propranolol, and benzodiazepines, representing both carrier-transported and lipophilic substances. In-diethylenetriamine pentaacetic acid, Na+, Cl-, L-glucose, and L-lysine were employed as reference substances. For all the substances tested, and after correction for intravascular phenomena, the extractions were found to increase during the initial part of the dilution curve. This increasing extraction can be ascribed to heterogeneity of the cerebral circulation; the higher extraction corresponds to longer contact with the blood-brain barrier and indicates a longer transit time. Signs of heterogeneity were also present when blood flow was elevated above normal. Any influence that heterogeneity might have on the mean extraction value can be minimized by using an appropriate calculation of the extraction of the test substance.",
keywords = "Blood Glucose/metabolism, Blood-Brain Barrier, Capillaries, Cerebrovascular Circulation, Clonazepam/blood, Diazepam/blood, Erythrocytes/metabolism, Humans, Indicator Dilution Techniques, Nitrazepam/blood, Permeability, Phenylalanine/blood, Propranolol/blood, Water/metabolism",
author = "Hertz, {M M} and Paulson, {O B}",
year = "1980",
month = may,
doi = "10.1172/JCI109769",
language = "English",
volume = "65",
pages = "1145--51",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "5",

}

RIS

TY - JOUR

T1 - Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability

AU - Hertz, M M

AU - Paulson, O B

PY - 1980/5

Y1 - 1980/5

N2 - Blood-brain barrier permeability studies made in man using the indicator dilution method revealed that the extraction of the test substance increases during the upslope of the venous (outflow) dilution curve. The present study aimed to obviate the possibility that this could result from intravascular phenomena, such as interlaminar diffusion (the result of differences in molecular size) and erythrocyte carriage. Several reference substances were employed for the determination of the extraction in order that careful correction could be made for differences in intravascular behavior of the test and reference substance. The test substances studied were D-glucose, L-phenylalanine, water, propranolol, and benzodiazepines, representing both carrier-transported and lipophilic substances. In-diethylenetriamine pentaacetic acid, Na+, Cl-, L-glucose, and L-lysine were employed as reference substances. For all the substances tested, and after correction for intravascular phenomena, the extractions were found to increase during the initial part of the dilution curve. This increasing extraction can be ascribed to heterogeneity of the cerebral circulation; the higher extraction corresponds to longer contact with the blood-brain barrier and indicates a longer transit time. Signs of heterogeneity were also present when blood flow was elevated above normal. Any influence that heterogeneity might have on the mean extraction value can be minimized by using an appropriate calculation of the extraction of the test substance.

AB - Blood-brain barrier permeability studies made in man using the indicator dilution method revealed that the extraction of the test substance increases during the upslope of the venous (outflow) dilution curve. The present study aimed to obviate the possibility that this could result from intravascular phenomena, such as interlaminar diffusion (the result of differences in molecular size) and erythrocyte carriage. Several reference substances were employed for the determination of the extraction in order that careful correction could be made for differences in intravascular behavior of the test and reference substance. The test substances studied were D-glucose, L-phenylalanine, water, propranolol, and benzodiazepines, representing both carrier-transported and lipophilic substances. In-diethylenetriamine pentaacetic acid, Na+, Cl-, L-glucose, and L-lysine were employed as reference substances. For all the substances tested, and after correction for intravascular phenomena, the extractions were found to increase during the initial part of the dilution curve. This increasing extraction can be ascribed to heterogeneity of the cerebral circulation; the higher extraction corresponds to longer contact with the blood-brain barrier and indicates a longer transit time. Signs of heterogeneity were also present when blood flow was elevated above normal. Any influence that heterogeneity might have on the mean extraction value can be minimized by using an appropriate calculation of the extraction of the test substance.

KW - Blood Glucose/metabolism

KW - Blood-Brain Barrier

KW - Capillaries

KW - Cerebrovascular Circulation

KW - Clonazepam/blood

KW - Diazepam/blood

KW - Erythrocytes/metabolism

KW - Humans

KW - Indicator Dilution Techniques

KW - Nitrazepam/blood

KW - Permeability

KW - Phenylalanine/blood

KW - Propranolol/blood

KW - Water/metabolism

U2 - 10.1172/JCI109769

DO - 10.1172/JCI109769

M3 - Journal article

C2 - 6988458

VL - 65

SP - 1145

EP - 1151

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 5

ER -

ID: 279596347