Effect of praziquantel on human lymphocyte proliferation in vitro
Research output: Contribution to journal › Journal article › Research › peer-review
The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.
Original language | English |
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Journal | European Journal of Clinical Pharmacology |
Volume | 27 |
Issue number | 3 |
Pages (from-to) | 311-3 |
Number of pages | 2 |
ISSN | 0031-6970 |
Publication status | Published - 1984 |
Bibliographical note
Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel
ID: 6767436