Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method. / Nymand, Stine B; Hartmann, Jacob Peter; Hartmeyer, Helene Louise; Rasmussen, Iben E; Andersen, Amalie Bach; Mohammad, Milan; Al-Atabi, Susan; Hanel, Birgitte; Iepsen, Ulrik Winning; Mortensen, Jann; Berg, Ronan M G.

In: Journal of visualized experiments : JoVE, No. 204, e65871, 02.02.2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nymand, SB, Hartmann, JP, Hartmeyer, HL, Rasmussen, IE, Andersen, AB, Mohammad, M, Al-Atabi, S, Hanel, B, Iepsen, UW, Mortensen, J & Berg, RMG 2024, 'Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method', Journal of visualized experiments : JoVE, no. 204, e65871. https://doi.org/10.3791/65871

APA

Nymand, S. B., Hartmann, J. P., Hartmeyer, H. L., Rasmussen, I. E., Andersen, A. B., Mohammad, M., Al-Atabi, S., Hanel, B., Iepsen, U. W., Mortensen, J., & Berg, R. M. G. (2024). Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method. Journal of visualized experiments : JoVE, (204), [e65871]. https://doi.org/10.3791/65871

Vancouver

Nymand SB, Hartmann JP, Hartmeyer HL, Rasmussen IE, Andersen AB, Mohammad M et al. Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method. Journal of visualized experiments : JoVE. 2024 Feb 2;(204). e65871. https://doi.org/10.3791/65871

Author

Nymand, Stine B ; Hartmann, Jacob Peter ; Hartmeyer, Helene Louise ; Rasmussen, Iben E ; Andersen, Amalie Bach ; Mohammad, Milan ; Al-Atabi, Susan ; Hanel, Birgitte ; Iepsen, Ulrik Winning ; Mortensen, Jann ; Berg, Ronan M G. / Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method. In: Journal of visualized experiments : JoVE. 2024 ; No. 204.

Bibtex

@article{ed596782916f45698d9242bda7fabf84,
title = "Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method",
abstract = "The combined single-breath measurement of the diffusing capacity of carbon monoxide (DL,CO) and nitric oxide (DL,NO) is a useful technique to measure pulmonary alveolar-capillary reserve in both healthy and patient populations. The measurement provides an estimate of the participant's ability to recruit and distend pulmonary capillaries. The method has recently been reported to exhibit a high test-retest reliability in healthy volunteers during exercise of light to moderate intensity. Of note, this technique permits up to 12 repeated maneuvers and only requires a single breath with a relatively short breath-hold time of 5 s. Representative data are provided showing the gradual changes in DL,NO and DL,CO from rest to exercise at increasing intensities of up to 60% of maximal workload. The measurement of diffusing capacity and evaluation of alveolar-capillary reserve is a useful tool to evaluate the lung's ability to respond to exercise both in the healthy population as well as in patient populations such as those with chronic lung disease.",
keywords = "Humans, Pulmonary Diffusing Capacity, Reproducibility of Results, Exercise, Lung, Carbon Monoxide, Nitric Oxide, Exercise Test",
author = "Nymand, {Stine B} and Hartmann, {Jacob Peter} and Hartmeyer, {Helene Louise} and Rasmussen, {Iben E} and Andersen, {Amalie Bach} and Milan Mohammad and Susan Al-Atabi and Birgitte Hanel and Iepsen, {Ulrik Winning} and Jann Mortensen and Berg, {Ronan M G}",
year = "2024",
month = feb,
day = "2",
doi = "10.3791/65871",
language = "English",
journal = "Journal of Visualized Experiments",
issn = "1940-087X",
publisher = "Journal of Visualized Experiments",
number = "204",

}

RIS

TY - JOUR

T1 - Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

AU - Nymand, Stine B

AU - Hartmann, Jacob Peter

AU - Hartmeyer, Helene Louise

AU - Rasmussen, Iben E

AU - Andersen, Amalie Bach

AU - Mohammad, Milan

AU - Al-Atabi, Susan

AU - Hanel, Birgitte

AU - Iepsen, Ulrik Winning

AU - Mortensen, Jann

AU - Berg, Ronan M G

PY - 2024/2/2

Y1 - 2024/2/2

N2 - The combined single-breath measurement of the diffusing capacity of carbon monoxide (DL,CO) and nitric oxide (DL,NO) is a useful technique to measure pulmonary alveolar-capillary reserve in both healthy and patient populations. The measurement provides an estimate of the participant's ability to recruit and distend pulmonary capillaries. The method has recently been reported to exhibit a high test-retest reliability in healthy volunteers during exercise of light to moderate intensity. Of note, this technique permits up to 12 repeated maneuvers and only requires a single breath with a relatively short breath-hold time of 5 s. Representative data are provided showing the gradual changes in DL,NO and DL,CO from rest to exercise at increasing intensities of up to 60% of maximal workload. The measurement of diffusing capacity and evaluation of alveolar-capillary reserve is a useful tool to evaluate the lung's ability to respond to exercise both in the healthy population as well as in patient populations such as those with chronic lung disease.

AB - The combined single-breath measurement of the diffusing capacity of carbon monoxide (DL,CO) and nitric oxide (DL,NO) is a useful technique to measure pulmonary alveolar-capillary reserve in both healthy and patient populations. The measurement provides an estimate of the participant's ability to recruit and distend pulmonary capillaries. The method has recently been reported to exhibit a high test-retest reliability in healthy volunteers during exercise of light to moderate intensity. Of note, this technique permits up to 12 repeated maneuvers and only requires a single breath with a relatively short breath-hold time of 5 s. Representative data are provided showing the gradual changes in DL,NO and DL,CO from rest to exercise at increasing intensities of up to 60% of maximal workload. The measurement of diffusing capacity and evaluation of alveolar-capillary reserve is a useful tool to evaluate the lung's ability to respond to exercise both in the healthy population as well as in patient populations such as those with chronic lung disease.

KW - Humans

KW - Pulmonary Diffusing Capacity

KW - Reproducibility of Results

KW - Exercise

KW - Lung

KW - Carbon Monoxide

KW - Nitric Oxide

KW - Exercise Test

U2 - 10.3791/65871

DO - 10.3791/65871

M3 - Journal article

C2 - 38372367

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

IS - 204

M1 - e65871

ER -

ID: 383342675