Do substance P and vasoactive intestinal polypeptide (VIP) play a role in the acute occlusive or chronic ischaemic vasodilation in man?
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Do substance P and vasoactive intestinal polypeptide (VIP) play a role in the acute occlusive or chronic ischaemic vasodilation in man? / Henriksen, Jens Henrik Sahl; Bülow, J B; Schaffalitzky de Muckadell, O; Fahrenkrug, J.
In: Clinical physiology (Oxford, England), Vol. 6, No. 2, 1986, p. 163-70.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Do substance P and vasoactive intestinal polypeptide (VIP) play a role in the acute occlusive or chronic ischaemic vasodilation in man?
AU - Henriksen, Jens Henrik Sahl
AU - Bülow, J B
AU - Schaffalitzky de Muckadell, O
AU - Fahrenkrug, J
N1 - Keywords: Aged; Arterial Occlusive Diseases; Humans; Ischemia; Leg; Middle Aged; Substance P; Vasoactive Intestinal Peptide
PY - 1986
Y1 - 1986
N2 - The concentrations of substance P (SP) and vasoactive intestinal polypeptide (VIP) were determined in plasma in normal volunteers during acute occlusive ischaemia (n=5) and in patients with chronic ischaemia (n=5) due to obliterative arterial disease in the lower limbs. Venous SP, but not VIP, increased significantly in the early post-occlusive period in normal volunteers (P less than 0.02). In the patients no significant veno-arterial difference in plasma concentration of SP or VIP could be detected across normal or chronic ischaemic areas. The results may suggest a role for SP in the acute post-occlusive vasodilation and/or in the post-occlusive heat-pain sensation. A role for SP in chronic ischaemia could not be defined. Plasma VIP was unchanged in both acute and chronic ischaemia.
AB - The concentrations of substance P (SP) and vasoactive intestinal polypeptide (VIP) were determined in plasma in normal volunteers during acute occlusive ischaemia (n=5) and in patients with chronic ischaemia (n=5) due to obliterative arterial disease in the lower limbs. Venous SP, but not VIP, increased significantly in the early post-occlusive period in normal volunteers (P less than 0.02). In the patients no significant veno-arterial difference in plasma concentration of SP or VIP could be detected across normal or chronic ischaemic areas. The results may suggest a role for SP in the acute post-occlusive vasodilation and/or in the post-occlusive heat-pain sensation. A role for SP in chronic ischaemia could not be defined. Plasma VIP was unchanged in both acute and chronic ischaemia.
M3 - Journal article
C2 - 2420506
VL - 6
SP - 163
EP - 170
JO - Clinical Physiology
JF - Clinical Physiology
SN - 0144-5979
IS - 2
ER -
ID: 18838199