DNA polymorphism of HLA class II genes in alopecia areata

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Standard

DNA polymorphism of HLA class II genes in alopecia areata. / Morling, N; Frentz, G; Fugger, L; Georgsen, J; Jakobsen, B; Ødum, Niels; Svejgaard, A.

In: Disease Markers, Vol. 9, No. 1, 1992, p. 35-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Morling, N, Frentz, G, Fugger, L, Georgsen, J, Jakobsen, B, Ødum, N & Svejgaard, A 1992, 'DNA polymorphism of HLA class II genes in alopecia areata', Disease Markers, vol. 9, no. 1, pp. 35-42.

APA

Morling, N., Frentz, G., Fugger, L., Georgsen, J., Jakobsen, B., Ødum, N., & Svejgaard, A. (1992). DNA polymorphism of HLA class II genes in alopecia areata. Disease Markers, 9(1), 35-42.

Vancouver

Morling N, Frentz G, Fugger L, Georgsen J, Jakobsen B, Ødum N et al. DNA polymorphism of HLA class II genes in alopecia areata. Disease Markers. 1992;9(1):35-42.

Author

Morling, N ; Frentz, G ; Fugger, L ; Georgsen, J ; Jakobsen, B ; Ødum, Niels ; Svejgaard, A. / DNA polymorphism of HLA class II genes in alopecia areata. In: Disease Markers. 1992 ; Vol. 9, No. 1. pp. 35-42.

Bibtex

@article{ffe3a160fd9711ddb219000ea68e967b,
title = "DNA polymorphism of HLA class II genes in alopecia areata",
abstract = "We investigated the DNA restriction polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DQA, -DQB, -DPA, and -DPB in 20 Danish patients with alopecia areata (AA) and in healthy Danes. The frequency in AA of the DQB1*0301 and DQw7 associated DQB Bgl/II 4.2 kb fragment was increased to 65.0 per cent compared to 23.2 per cent in controls (RR = 6.1; p less than 10(-3)) suggesting that the previously reported associations between AA and both DR4 and DR5 is secondary to an association between AA and DQB1*0301, which codes for the beta-chain of the HLA-DQ molecule of the serologically defined HLA-DQw7 specificity. Individuals who carried both DQA1*0501 and DQB1*0301 seemed to have a further increased risk of developing AA compared to individuals carrying only one of these HLA class II genes. Analysis of the combined presence of DQB1*0301 and DPA1*0103 in AA suggests that an additive risk effect (synergism or interaction) exists between the DQB1*0301 and DPA1*0103 alleles which are situated at different HLA class II loci.",
author = "N Morling and G Frentz and L Fugger and J Georgsen and B Jakobsen and Niels {\O}dum and A Svejgaard",
note = "Keywords: Alopecia Areata; DNA; Denmark; Genes, MHC Class II; Genetic Markers; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Polymorphism, Restriction Fragment Length",
year = "1992",
language = "English",
volume = "9",
pages = "35--42",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "Hindawi Publishing Corporation",
number = "1",

}

RIS

TY - JOUR

T1 - DNA polymorphism of HLA class II genes in alopecia areata

AU - Morling, N

AU - Frentz, G

AU - Fugger, L

AU - Georgsen, J

AU - Jakobsen, B

AU - Ødum, Niels

AU - Svejgaard, A

N1 - Keywords: Alopecia Areata; DNA; Denmark; Genes, MHC Class II; Genetic Markers; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Polymorphism, Restriction Fragment Length

PY - 1992

Y1 - 1992

N2 - We investigated the DNA restriction polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DQA, -DQB, -DPA, and -DPB in 20 Danish patients with alopecia areata (AA) and in healthy Danes. The frequency in AA of the DQB1*0301 and DQw7 associated DQB Bgl/II 4.2 kb fragment was increased to 65.0 per cent compared to 23.2 per cent in controls (RR = 6.1; p less than 10(-3)) suggesting that the previously reported associations between AA and both DR4 and DR5 is secondary to an association between AA and DQB1*0301, which codes for the beta-chain of the HLA-DQ molecule of the serologically defined HLA-DQw7 specificity. Individuals who carried both DQA1*0501 and DQB1*0301 seemed to have a further increased risk of developing AA compared to individuals carrying only one of these HLA class II genes. Analysis of the combined presence of DQB1*0301 and DPA1*0103 in AA suggests that an additive risk effect (synergism or interaction) exists between the DQB1*0301 and DPA1*0103 alleles which are situated at different HLA class II loci.

AB - We investigated the DNA restriction polymorphism (RFLP) of the Major Histocompatibility Complex (MHC) class II genes: HLA-DQA, -DQB, -DPA, and -DPB in 20 Danish patients with alopecia areata (AA) and in healthy Danes. The frequency in AA of the DQB1*0301 and DQw7 associated DQB Bgl/II 4.2 kb fragment was increased to 65.0 per cent compared to 23.2 per cent in controls (RR = 6.1; p less than 10(-3)) suggesting that the previously reported associations between AA and both DR4 and DR5 is secondary to an association between AA and DQB1*0301, which codes for the beta-chain of the HLA-DQ molecule of the serologically defined HLA-DQw7 specificity. Individuals who carried both DQA1*0501 and DQB1*0301 seemed to have a further increased risk of developing AA compared to individuals carrying only one of these HLA class II genes. Analysis of the combined presence of DQB1*0301 and DPA1*0103 in AA suggests that an additive risk effect (synergism or interaction) exists between the DQB1*0301 and DPA1*0103 alleles which are situated at different HLA class II loci.

M3 - Journal article

C2 - 1683825

VL - 9

SP - 35

EP - 42

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

IS - 1

ER -

ID: 10636540