Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study

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Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading : An immunohistochemical study. / Sakuma, Kunihiro; Watanabe, Kimi; Totsuka, Tsuyoshi; Uramoto, Isao; Sano, Mamoru; Sakamoto, Kei.

In: Acta Neuropathologica, Vol. 95, No. 2, 01.01.1998, p. 123-130.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sakuma, K, Watanabe, K, Totsuka, T, Uramoto, I, Sano, M & Sakamoto, K 1998, 'Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study', Acta Neuropathologica, vol. 95, no. 2, pp. 123-130. https://doi.org/10.1007/s004010050775

APA

Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M., & Sakamoto, K. (1998). Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study. Acta Neuropathologica, 95(2), 123-130. https://doi.org/10.1007/s004010050775

Vancouver

Sakuma K, Watanabe K, Totsuka T, Uramoto I, Sano M, Sakamoto K. Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study. Acta Neuropathologica. 1998 Jan 1;95(2):123-130. https://doi.org/10.1007/s004010050775

Author

Sakuma, Kunihiro ; Watanabe, Kimi ; Totsuka, Tsuyoshi ; Uramoto, Isao ; Sano, Mamoru ; Sakamoto, Kei. / Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading : An immunohistochemical study. In: Acta Neuropathologica. 1998 ; Vol. 95, No. 2. pp. 123-130.

Bibtex

@article{37dea337e73744c3a9622583617ee90f,
title = "Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study",
abstract = "We investigated changes in several growth factors in the rat plantaris muscle produced by mechanical overloading by ablation of synergists using immunohistochemistry. At 1 and 3 days post surgery, the insulin-like growth factor-I (IGF-I) level was slightly increased in the cytosol and markedly increased in the invading cells of the extracellular space. Thereafter, the IGF-I immunoreactivity evoked by overloading rapidly decreased to the normal level. The level of leukemia inhibitory factor (LIF), which was not shown to change at 1 day post surgery, was increased in the cytosol at 3, 5, 7 and 10 days and at 2 weeks. Basic fibroblast growth factor (bFGF) immunoreactivity did not change during the entire period of overloading (1 day-3 weeks post surgery). These results indicate that the elevations of the levels of IGF-I and LIF show differential time course in the plantaris muscle subjected to functional overload. Furthermore, bFGF appears not to be related to the compensatory hypertrophy produced by overloading.",
keywords = "Fibroblast growth factor, Insulin-like growth factor, Leukemia inhibitory factor, Mechanical overloading, Muscle hypertrophy",
author = "Kunihiro Sakuma and Kimi Watanabe and Tsuyoshi Totsuka and Isao Uramoto and Mamoru Sano and Kei Sakamoto",
year = "1998",
month = jan,
day = "1",
doi = "10.1007/s004010050775",
language = "English",
volume = "95",
pages = "123--130",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading

T2 - An immunohistochemical study

AU - Sakuma, Kunihiro

AU - Watanabe, Kimi

AU - Totsuka, Tsuyoshi

AU - Uramoto, Isao

AU - Sano, Mamoru

AU - Sakamoto, Kei

PY - 1998/1/1

Y1 - 1998/1/1

N2 - We investigated changes in several growth factors in the rat plantaris muscle produced by mechanical overloading by ablation of synergists using immunohistochemistry. At 1 and 3 days post surgery, the insulin-like growth factor-I (IGF-I) level was slightly increased in the cytosol and markedly increased in the invading cells of the extracellular space. Thereafter, the IGF-I immunoreactivity evoked by overloading rapidly decreased to the normal level. The level of leukemia inhibitory factor (LIF), which was not shown to change at 1 day post surgery, was increased in the cytosol at 3, 5, 7 and 10 days and at 2 weeks. Basic fibroblast growth factor (bFGF) immunoreactivity did not change during the entire period of overloading (1 day-3 weeks post surgery). These results indicate that the elevations of the levels of IGF-I and LIF show differential time course in the plantaris muscle subjected to functional overload. Furthermore, bFGF appears not to be related to the compensatory hypertrophy produced by overloading.

AB - We investigated changes in several growth factors in the rat plantaris muscle produced by mechanical overloading by ablation of synergists using immunohistochemistry. At 1 and 3 days post surgery, the insulin-like growth factor-I (IGF-I) level was slightly increased in the cytosol and markedly increased in the invading cells of the extracellular space. Thereafter, the IGF-I immunoreactivity evoked by overloading rapidly decreased to the normal level. The level of leukemia inhibitory factor (LIF), which was not shown to change at 1 day post surgery, was increased in the cytosol at 3, 5, 7 and 10 days and at 2 weeks. Basic fibroblast growth factor (bFGF) immunoreactivity did not change during the entire period of overloading (1 day-3 weeks post surgery). These results indicate that the elevations of the levels of IGF-I and LIF show differential time course in the plantaris muscle subjected to functional overload. Furthermore, bFGF appears not to be related to the compensatory hypertrophy produced by overloading.

KW - Fibroblast growth factor

KW - Insulin-like growth factor

KW - Leukemia inhibitory factor

KW - Mechanical overloading

KW - Muscle hypertrophy

UR - http://www.scopus.com/inward/record.url?scp=0031885737&partnerID=8YFLogxK

U2 - 10.1007/s004010050775

DO - 10.1007/s004010050775

M3 - Journal article

C2 - 9498045

AN - SCOPUS:0031885737

VL - 95

SP - 123

EP - 130

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 2

ER -

ID: 239779635