Dietary α-linolenic acid, marine ω-3 fatty acids, and mortality in a population with high fish consumption: Findings from the PREvención con DIeta MEDiterránea (PREDIMED) Study
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Dietary α-linolenic acid, marine ω-3 fatty acids, and mortality in a population with high fish consumption : Findings from the PREvención con DIeta MEDiterránea (PREDIMED) Study. / Sala-Vila, Aleix; Guasch-Ferré, Marta; Hu, Frank B.; Sánchez-Tainta, Ana; Bulló, Mònica; Serra-Mir, Mercè; López-Sabater, Carmen; Sorlí, Jose V.; Arós, Fernando; Fiol, Miquel; Muñoz, Miguel A.; Serra-Majem, Luis; Alfredo Martínez, J.; Corella, Dolores; Fitó, Montserrat; Salas-Salvadó, Jordi; Martínez-González, Miguel A.; Estruch, Ramón; Ros, Emilio; for the PREDIMED Investigators.
In: Journal of the American Heart Association, Vol. 5, No. 1, e002543, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary α-linolenic acid, marine ω-3 fatty acids, and mortality in a population with high fish consumption
T2 - Findings from the PREvención con DIeta MEDiterránea (PREDIMED) Study
AU - Sala-Vila, Aleix
AU - Guasch-Ferré, Marta
AU - Hu, Frank B.
AU - Sánchez-Tainta, Ana
AU - Bulló, Mònica
AU - Serra-Mir, Mercè
AU - López-Sabater, Carmen
AU - Sorlí, Jose V.
AU - Arós, Fernando
AU - Fiol, Miquel
AU - Muñoz, Miguel A.
AU - Serra-Majem, Luis
AU - Alfredo Martínez, J.
AU - Corella, Dolores
AU - Fitó, Montserrat
AU - Salas-Salvadó, Jordi
AU - Martínez-González, Miguel A.
AU - Estruch, Ramón
AU - Ros, Emilio
AU - for the PREDIMED Investigators
N1 - Publisher Copyright: © 2016 The Authors.
PY - 2016
Y1 - 2016
N2 - Background-Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids.
AB - Background-Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids.
KW - Fatty acid
KW - Nutrition
KW - Sudden cardiac death
U2 - 10.1161/JAHA.115.002543
DO - 10.1161/JAHA.115.002543
M3 - Journal article
C2 - 26813890
AN - SCOPUS:84998579388
VL - 5
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 1
M1 - e002543
ER -
ID: 358502680